Fevipiprant in the treatment of asthma.

Abstract

INTRODUCTION:

Asthma is common and in many, particularly those with more severe disease, there remains a substantial unmet need. Success with biologics targeting eosinophilic inflammation underscore the value of treating inflammation in asthma beyond corticosteroids. Fevipiprant (QAW039) is an oral treatment for asthma. It competitively and reversibly antagonises the prostaglandin D2 receptor 2 (DP2) expressed on inflammatory and structural cells. Areas covered: We reviewed fevipiprant's mode of action and efficacy against other current and emerging pharmacological interventions for moderate-to-severe asthma. We undertook a literature review using the PubMed/Medline database, the U.S. National Library of Medicine's Clinical Trials website and from manufacturers' press releases with the search terms: 'QAW039', 'Fevipiprant', 'CRTH2 antagonists', 'DP2', 'DP1', 'monoclonal antibody', 'eosinophil' with 'asthma' plus the names of individual drugs. Three Phase 2 trials have been conducted and three Phase 3 trials (NCT02563067, NCT03052517, NCT02555683) are in progress. To date Fevipiprant's greatest success has been in targeting severe eosinophilic asthma. Expert opinion: Fevipiprant presents the possibility of a new orally active therapy for asthma. If successful in phase 3 trials it will have an enormous impact on the treatment paradigm for asthma and will potentially widen access for pre-biologic treatment to a larger population.

• Authors: Christobelle White, Adam Wright, Christopher Brightling
• Journal: Expert opinion on investigational drugs (Expert Opin Investig Drugs) Vol. 27 Issue 2 Pg. 199-207 (Feb 2018) ISSN: 1744-7658 [Electronic] England
• PMID: 29363343 (Publication Type: Journal Article, Review)

Chemical References

• Anti-Asthmatic Agents
• Indoleacetic Acids
• Pyridines
• fevipiprant

Topics

• Administration, Oral
• Anti-Asthmatic Agents (administration & dosage, pharmacology, therapeutic use)
• Asthma (drug therapy, physiopathology)
• Eosinophils (metabolism)
• Humans
• Indoleacetic Acids (administration & dosage, pharmacology, therapeutic use)
• Inflammation (drug therapy, physiopathology)
• Pyridines (administration & dosage, pharmacology, therapeutic use)
• Severity of Illness Index