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Enantioselective Synthesis of Boryl Tetrahydroquinolines via Cu-Catalyzed Hydroboration.

Abstract
A Cu-catalyzed regio- and enantioselective hydroboration of 1,2-dihydroquinolines with high yields and excellent enantioselectivities (up to 98% ee) was presented. This method could be applied in the asymmetric synthesis of the important intermediates used in the enantioselective synthesis of the potential agent Sumanirole for the treatment of Parkinson's disease and of the potentially interesting positive inotropic agent (S)-903.
AuthorsDuanyang Kong, Suna Han, Guofu Zi, Guohua Hou, Jiaxin Zhang
JournalThe Journal of organic chemistry (J Org Chem) Vol. 83 Issue 4 Pg. 1924-1932 (02 16 2018) ISSN: 1520-6904 [Electronic] United States
PMID29345126 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

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