The use of hyaluronic and aminocaproic acid in the treatment of alveolar osteitis.

Abstract

Background/Aim:

Alveolar osteitis (AO), also known as “dry socket”, is relatively common post-extraction complication. It probably occurs due to excessive fibrinolytic activity in the coagulum and is characterized by intense pain sensations. The aim of this clinical study was to examine the role of hyaluronic acid and aminocaproic acid in the treatment of AO.

Methods:

The study included 60 patients with the clinical diagnosis of AO. All the patients were divided into two groups of 30 patients each according to the applied non-pharmacological measure: irrigation – irrigation of dry socket with sterile saline; curettage – careful curettage. Both of these groups were further divided into three subgroups regarding the applied treatment (hyaluronic acid; hyaluronic acid + aminocaproic acid; Alvogyl ®, an anesthetic and antiseptic paste), each with 10 patients, according to the following protocol: 0.2 mL of hyaluronic acid in the form of a 0.8% gel; 2 mL of aminocaproic acid and hyaluronic acid; Alvogyl®. During each visit, scheduled for every two days until complete absence of painful sensations, the patients had the therapeutic method repeated as at the first examination. At each control visit the number of present symptoms and signs of AO was recorded, as well as the level of pain (measured with a visual analogue scale).

Results:

With the use of hyaluronic acid, with or without aminocaproic one, a statistically significantly faster reduction in pain sensations was achieved, along with the reduction in the number of symptoms and signs of AO compared to the use of Alvogyl®.

Conclusion:

Hyaluronic acid, applied alone or in combination with aminocaproic acid significantly reduces pain sensation, thus it can be successfully used in the treatment of AO.

• Authors: Dejan Dubovina, Branko Mihailović, Zoran Bukumirić, Zoran Vlahović, Milan Miladinović, Nikola Miković, Zoran Lazić
• Journal: Vojnosanitetski pregled (Vojnosanit Pregl) Vol. 73 Issue 11 Pg. 1010-5 (Nov 2016) ISSN: 0042-8450 [Print] Serbia
• PMID: 29328639 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Analgesics
• Drug Combinations
• Hydrocarbons, Iodinated
• Oils, Volatile
• butyl aminobenzoate, eugenol, iodoform, spearmint oil drug combinations
• para-Aminobenzoates
• Eugenol
• Hyaluronic Acid
• Aminocaproic Acid

Topics

• Adult
• Aminocaproic Acid (adverse effects, therapeutic use)
• Analgesics (adverse effects, therapeutic use)
• Curettage (adverse effects)
• Drug Combinations
• Dry Socket (diagnosis, drug therapy)
• Eugenol (adverse effects, therapeutic use)
• Facial Pain (diagnosis, etiology, physiopathology, prevention & control)
• Female
• Humans
• Hyaluronic Acid (adverse effects, therapeutic use)
• Hydrocarbons, Iodinated (adverse effects, therapeutic use)
• Male
• Middle Aged
• Oils, Volatile (adverse effects, therapeutic use)
• Pain Measurement
• Pain Perception (drug effects)
• Pain Threshold (drug effects)
• Prospective Studies
• Serbia
• Therapeutic Irrigation
• Time Factors
• Treatment Outcome
• para-Aminobenzoates (adverse effects, therapeutic use)