Prospective, randomized, blinded, and placebo-controlled study of Cerebrolysin dose-response effects on long-term functional outcomes in a rat model of mild traumatic brain injury.

Abstract

Using a prospective, randomized, blinded, placebo-controlled protocol, the authors demonstrated that Cerebrolysin at doses of 0.8-7.5 ml/kg, administered 4 hours after injury and then once daily for a total of 10 consecutive days, improves long-term functional outcomes in a rat model of mild closed head injury; a 2.5-ml/kg dose was identified as optimal. These findings suggest that Cerebrolysin has the potential to treat mild traumatic brain injury, the incidence of which is high without effective treatments.

• Authors: Yanlu Zhang, Michael Chopp, Zheng Gang Zhang, Yi Zhang, Li Zhang, Mei Lu, Talan Zhang, Stefan Winter, Hemma Brandstätter, Asim Mahmood, Ye Xiong
• Journal: Journal of neurosurgery (J Neurosurg) Vol. 129 Issue 5 Pg. 1295-1304 (11 01 2018) ISSN: 1933-0693 [Electronic] United States
• PMID: 29303438 (Publication Type: Journal Article)

Chemical References

• Amino Acids
• Neuroprotective Agents
• cerebrolysin

Topics

• Amino Acids (pharmacology, therapeutic use)
• Animals
• Brain Concussion (drug therapy)
• Cognition (drug effects)
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Double-Blind Method
• Male
• Maze Learning (drug effects)
• Neuroprotective Agents (pharmacology, therapeutic use)
• Rats
• Rats, Wistar
• Recovery of Function (drug effects)
• Treatment Outcome