Abstract |
It has been suggested that anti- desmoglein autoantibody titers could be helpful in follow-up and therapeutic management of pemphigus patients. However, there is no consensus regarding the relationship between anti- desmoglein autoantibody titers and clinical activity of pemphigus.The aim of our study was to evaluate if clinical remission of pemphigus relates to the presence of anti- desmoglein autoantibodies.Thirty patients with pemphigus vulgaris and 7 patients with pemphigus foliaceous were included in the study. Assessment of autoantibody titers was carried out at the time of the initial diagnosis and after the clinical remission using an enzyme-linked immunosorbent assay-based assay.Our results indicate that pemphigus clinical remission did not necessarily imply a serological remission, and consequently it is necessary to establish if withdrawal of the immunosuppressive regimen in pemphigus should be based exclusively on the achievement of clinical remission or also on the serological findings.
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Authors | Irene Russo, Francesco Paolo De Siena, Andrea Saponeri, Mauro Alaibac |
Journal | Medicine
(Medicine (Baltimore))
Vol. 96
Issue 46
Pg. e8801
(Nov 2017)
ISSN: 1536-5964 [Electronic] United States |
PMID | 29145342
(Publication Type: Evaluation Study, Journal Article)
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Chemical References |
- Autoantibodies
- DSG1 protein, human
- DSG3 protein, human
- Desmoglein 1
- Desmoglein 3
- Immunosuppressive Agents
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Topics |
- Autoantibodies
(blood)
- Desmoglein 1
(immunology)
- Desmoglein 3
(immunology)
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Male
- Middle Aged
- Pemphigus
(blood, drug therapy, immunology)
- Remission Induction
- Treatment Outcome
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