Review: interactions between H2-antagonists and non-steroidal anti-inflammatory drugs.

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are being prescribed increasingly with an H2-antagonist. This article reviews those published studies which have examined the potential for pharmacokinetic and, where appropriate, pharmacodynamic interactions between these classes of drugs. Studies involving the administration of a single dose of a NSAID to young healthy volunteers are of limited relevance in establishing the likely effect of an H2-antagonist on the blood concentrations of an NSAID in patients. Appropriate studies are those which will examine the effects of H2-antagonists on the steady-state pharmacokinetics of NSAIDs in patients with inflammatory joint diseases. More of such studies are required, particularly involving elderly patients.

• Authors: C W Howden
• Journal: Alimentary pharmacology & therapeutics (Aliment Pharmacol Ther) Vol. 2 Issue 2 Pg. 93-100 (Apr 1988) ISSN: 0269-2813 [Print] England
• PMID: 2908753 (Publication Type: Journal Article, Review)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Histamine H2 Antagonists

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (pharmacokinetics, therapeutic use)
• Drug Interactions
• Histamine H2 Antagonists (adverse effects, therapeutic use)
• Humans