Abstract | OBJECTIVE: STUDY DESIGN: Data come from a historical prospective cohort study (Exploring Perinatal Outcomes in Children) of 254 mother-child pairs in Colorado who participated in 2 research visits at T1 (mean age 10.4, SD = 1.5 years) and at T2 (mean age 16.4, SD = 1.5 years), and had complete exposure and outcome data. Multiple linear regression was used to evaluate the effects of pre-pregnancy body mass index (BMI) and GDM on hepatic fat fraction (HFF) by magnetic resonance imaging at T2. RESULTS: Maternal pre-pregnancy obesity (BMI 30+) was significantly associated (β = 1.59, CI = 0.66, 2.52) with increased HFF relative to mothers with normal pre-pregnancy weight (BMI <25) independent of maternal GDM and sociodemographic factors. Moreover, this association was independent of T2 and T1 metabolic risk factors ( acanthosis nigricans, BMI, fasting glucose) (β = 1.03, CI = 0.10, 1.97). Prenatal GDM exposure was not associated with HFF in either unadjusted or adjusted models. CONCLUSIONS: Maternal pre-pregnancy obesity was associated with increased HFF in offspring independent of childhood and adolescent adiposity. Intervention studies are needed to test the hypothesis that maternal obesity is a modifiable risk factor for childhood fatty liver disease.
|
Authors | Anna Bellatorre, Ann Scherzinger, Elizabeth Stamm, Mercedes Martinez, Brandy Ringham, Dana Dabelea |
Journal | The Journal of pediatrics
(J Pediatr)
Vol. 192
Pg. 165-170.e1
(01 2018)
ISSN: 1097-6833 [Electronic] United States |
PMID | 29046229
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
|
Copyright | Copyright © 2017 Elsevier Inc. All rights reserved. |
Topics |
- Adolescent
- Child
- Diabetes, Gestational
- Fatty Liver
(diagnostic imaging, etiology)
- Female
- Follow-Up Studies
- Humans
- Linear Models
- Magnetic Resonance Imaging
- Male
- Obesity
(complications)
- Overnutrition
(complications)
- Pregnancy
- Prenatal Exposure Delayed Effects
(diagnostic imaging, etiology)
- Prospective Studies
- Risk Factors
|