Expression of Neurotrophin-3 and trkC following Focal Cerebral Ischemia in Adult Rat Brain with Treadmill Exercise.

Abstract

Neurotrophin-3 (NT-3) is a neurotrophic factor that mainly binds to the tyrosine kinase C (trkC) receptor. NT-3 has been shown to have neuroprotective effects in focal cerebral ischemia. Exercise also has ability to induce functional recovery in focal cerebral ischemia. However, the relationship between NT-3, its receptor trkC, and exercise has not been revealed. In this study, we assessed the expressions of NT-3 and trkC in focal cerebral ischemia. We also assessed the expression of NT-3 and trkC with treadmill exercise in focal cerebral ischemia. The results showed that, in a permanent middle cerebral artery occlusion rat model, exercise increased NT-3 and trkC expression. However, the patterns of expression of NT-3 and trkC at different time points varied. These results suggest that exercise-induced functional recovery in focal cerebral ischemia was related to NT-3 and trkC, but the role on times of NT-3 and trkC differed, although trkC is the receptor kinase for NT-3.

• Authors: Jin-Young Chung, Min-Wook Kim, Wooseok Im, In Koo Hwang, Moon-Suk Bang, Manho Kim
• Journal: BioMed research international (Biomed Res Int) Vol. 2017 Pg. 9248542 ( 2017) ISSN: 2314-6141 [Electronic] United States
• PMID: 29018822 (Publication Type: Journal Article)

Chemical References

• Neuroprotective Agents
• Neurotrophin 3
• Protein-Tyrosine Kinases
• Receptor Protein-Tyrosine Kinases

Topics

• Animals
• Brain (metabolism)
• Brain Ischemia (metabolism)
• Exercise Test (methods)
• Infarction, Middle Cerebral Artery (metabolism)
• Male
• Neurons (metabolism)
• Neuroprotective Agents (metabolism)
• Neurotrophin 3 (metabolism)
• Physical Conditioning, Animal (physiology)
• Protein-Tyrosine Kinases (metabolism)
• Rats
• Rats, Sprague-Dawley
• Receptor Protein-Tyrosine Kinases (metabolism)
• Recovery of Function (physiology)