Effect of Electroconvulsive Therapy on Cognitive Functions of Rats with Depression-Like Disorders Induced by Ultrasound Exposure.

Abstract

We studied the effect of electroconvulsive therapy on cognitive functions in rats with depression-like disorder caused by exposure to ultrasound of varying frequency (20-45 kHz). Object recognition and Morris water-maze tests revealed no negative effects of the therapy on memory. Moreover, positive effect of therapy was demonstrated that manifested in amelioration of memory disturbances in depression-like disorders in these behavioral tests. The results of this study do not support the idea about side effects of electroconvulsive therapy, in particular, development of transient amnesia, and are a prerequisite for a more thorough study of internal mechanisms of the effect of the therapy on cognitive sphere.

• Authors: V M Ushakova, E A Zubkov, A Y Morozova, A V Gorlova, D A Pavlov, A N Inozemtsev, V P Chekhonin
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 163 Issue 5 Pg. 599-601 (Sep 2017) ISSN: 1573-8221 [Electronic] United States
• PMID: 28948550 (Publication Type: Journal Article)

Topics

• Animals
• Cognition (radiation effects)
• Depression (etiology, therapy)
• Electroconvulsive Therapy (methods)
• Male
• Memory (radiation effects)
• Rats
• Ultrasonic Waves (adverse effects)