Orofacial granulomatosis in a 12-year-old girl successfully treated with intravenous pulse corticosteroid therapy and chloroquine.

Abstract

Orofacial granulomatosis, a rare disease in childhood, is characterized by orofacial swelling in the absence of systemic disease. We report the case of a 12-year-old girl with asymptomatic erythematous infiltration of her upper lip, cheeks, and chin that had persisted for more than 2 years; biopsy confirmed granuloma formation. Because a large area was affected, intralesional corticosteroids were inappropriate and six cycles of 3-day intravenous pulse corticosteroid therapy (dexamethasone 1.5mg/kg), repeated once after 4 weeks, was given. Our patient also received oral chloroquine and topical emollients. At the end of the sixth pulse cycle, the infiltration had completely resolved, leaving slight residual erythema.

• Authors: Jovan Lalosevic, Mirjana Gajic-Veljic, Milos Nikolic
• Journal: Pediatric dermatology (Pediatr Dermatol) Vol. 34 Issue 6 Pg. e324-e327 (Nov 2017) ISSN: 1525-1470 [Electronic] United States
• PMID: 28940800 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2017 Wiley Periodicals, Inc.

Chemical References

• Antirheumatic Agents
• Glucocorticoids
• Chloroquine

Topics

• Antirheumatic Agents (therapeutic use)
• Child
• Chloroquine (therapeutic use)
• Female
• Glucocorticoids (administration & dosage)
• Granulomatosis, Orofacial (drug therapy, pathology)
• Humans
• Pulse Therapy, Drug
• Skin (pathology)