Radioiodine-labeled anti-epidermal growth factor receptor binding bovine serum albumin-polycaprolactone for targeting imaging of glioblastoma.

Abstract	The aim of this study was to look for a new medicine in diagnosing and treating of glioblastoma. Radioiodine-labeled anti-epidermal growth factor receptor (EGFR) binding nanoparticles were constructed. In vitro cell-binding assays were confirmed by confocal microscopy and flow cytometry. Cell cytotoxicity assays were evaluated by MTT assay; radionuclide uptake assays were performed by γ-counter. Radioiodine-imaging studies were conducted using a xenograft nude mouse model in vivo. The results showed that EGFR significantly enhanced the uptake and accumulation of BSA-PCL in the experimental model of xenografts in nude mice, suggesting improved specific nanoparticle-based delivery. In conclusion, the data showed 131I-EGFR-BSA-PCL leading radioiodine therapy for U251 and U87 cells had a good effect in vitro and in vivo. Thus, 131I-EGFR-BSA-PCL may provide a new method for glioblastoma treatment.
Authors	Chengxia Li, Jian Tan, Jin Chang, Wei Li, Zhongyun Liu, Ning Li, Yanhui Ji
Journal	Oncology reports (Oncol Rep) Vol. 38 Issue 5 Pg. 2919-2926 (Nov 2017) ISSN: 1791-2431 [Electronic] Greece
PMID	28901480 (Publication Type: Journal Article)
Chemical References	Iodine Radioisotopes Polyesters Radiopharmaceuticals polycaprolactone Serum Albumin, Bovine EGFR protein, human ErbB Receptors Cetuximab
Topics	Animals Brain Neoplasms (diagnostic imaging, drug therapy, metabolism) Cattle Cell Line, Tumor Cell Survival (drug effects) Cetuximab (administration & dosage, chemistry, pharmacology) ErbB Receptors (metabolism) Glioblastoma (diagnostic imaging, drug therapy, metabolism) Humans Iodine Radioisotopes (administration & dosage, chemistry) Mice Nanoparticles (administration & dosage, chemistry) Neoplasm Transplantation Polyesters (administration & dosage, chemistry) Radiopharmaceuticals (administration & dosage, chemistry) Serum Albumin, Bovine (administration & dosage, chemistry) Tomography, Emission-Computed, Single-Photon (methods) Xenograft Model Antitumor Assays

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