Usefulness of a topical combination of dinotefuran and pyriproxyfen for long-term control of clinical signs of allergic dermatitis in privately-owned cats in Ile-de-France region.

Abstract

BACKGROUND:

The present study assessed the activity of a combination of dinotefuran and pyriproxyfen (Vectra® Felis) for long-term control (3 months) of allergic dermatitis (AD) in privately-owned cats under common household conditions in Ile-de-France region.

METHODS:

This was an open pre-treatment vs post-treatment study. Twenty-eight client-owned cats with clinical signs of AD were enrolled in the study. They received topical application of the combination of dinotefuran and pyriproxyfen on days 0, 28, 56 and 84. Two parameters (clinical signs and pruritus severity) were used to assess the animals' condition on days 0, 28 and 84. Fleas were counted if they were observed.

RESULTS:

Of the 28 cats initially enrolled, 26 were presented on day 28 and 20 for the final evaluation on day 84. A significant improvement in clinical signs and pruritus was observed in cats for which fleas and/or flea feces were detected on day 0. Globally, the post-treatment AD clinical scores on days 28 and 84 were different from that of the pre-treatment on day 0, with a reduction of 30% and 71%, respectively. For cats with fleas and/or flea feces, the reduction on days 28 and 84 was 33% and 85%, respectively. The improvement of clinical signs and pruritus was not significant in cats with no visible fleas and no flea feces at the beginning of the trial (n = 8).

CONCLUSIONS:

The present study indicated that the treatment with a combination of dinotefuran and pyriproxyfen should be considered as useful in controlling fleas on cats without additional environmental treatment and useful for long-term control of clinical signs and pruritus in allergic cats.

• Authors: Odile Crosaz, Silvia Bonati, Amaury Briand, Elodie Chapelle, Noëlle Cochet-Faivre, Diane Ka, Céline Darmon-Hadjaje, Marie Varloud, Jacques Guillot
• Journal: Parasites & vectors (Parasit Vectors) Vol. 10 Issue 1 Pg. 392 (Aug 23 2017) ISSN: 1756-3305 [Electronic] England
• PMID: 28830567 (Publication Type: Journal Article)

Chemical References

• Guanidines
• Insecticides
• Neonicotinoids
• Nitro Compounds
• Pyridines
• dinotefuran
• pyriproxyfen

Topics

• Administration, Topical
• Animals
• Cat Diseases (drug therapy)
• Cats
• Dermatitis, Atopic (drug therapy, veterinary)
• Drug Therapy, Combination
• Female
• Flea Infestations (drug therapy, veterinary)
• France
• Guanidines (administration & dosage, therapeutic use)
• Insecticides (therapeutic use)
• Male
• Neonicotinoids (administration & dosage, therapeutic use)
• Nitro Compounds (administration & dosage, therapeutic use)
• Pets (parasitology)
• Pruritus (drug therapy, veterinary)
• Pyridines (administration & dosage, therapeutic use)
• Siphonaptera (drug effects)