Beneficial Effects of Oral Iron in Japanese Patients on Hemodialysis.

Abstract

Objective Iron deficiency anemia (IDA) has become important with regard to mortality in hemodialysis (HD) patients. Therefore, it is necessary to optimize the treatment of these patients. Methods IDA in end-stage renal disease patients on HD was observed in 42 (33.6%) of 125 patients. We examined the influence of daily orally iron [sodium ferrous citrate (SFC) iron/tablet 50 mg, 1-2 tablets] on the renal function markers, anemia and iron data for about 6 months. Results The hematocrit and hemoglobin levels were significantly increased in the patients treated with SFC [hematocrit: before 28.5%±2.1% (mean ± standard deviation), 1st month 30.0%±2.3%, p<0.05; 3rd month 32.4%±2.9%, p<0.05; 6th month 31.3%±3.4%, p<0.05; and hemoglobin: before 9.25±0.70, 1st month 9.72±0.71, p<0.05; 3rd month 10.54±0.96, p<0.05; 6th month 10.25±1.21 g/dL, p<0.05]. The transferrin saturation (TSAT) and serum ferritin levels were significantly increased in the patients treated with SFC (TSAT: before 21.5%±10.0%, 1st-3rd month, 34.1%±15.1%, p<0.05; 6-8th month 34.7%±11.9%, p<0.05; and ferritin: before 38.2±37.1, 6-8th month 67.5±44.0 ng/mL, p<0.05). The present findings clearly indicate that oral iron is an effective route of iron supplementation in HD patients, and no adverse effects associated with SFC occurred during the treatment and follow-up period. Conclusion Our results clearly indicate that oral iron delivered via SFC is a well-tolerated and effective form of iron supplementation in long-term HD and IDA patients in Japan.

• Authors: Toru Sanai, Takashi Ono, Toma Fukumitsu
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 56 Issue 18 Pg. 2395-2399 (Sep 15 2017) ISSN: 1349-7235 [Electronic] Japan
• PMID: 28824065 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Ferrous Compounds
• Hemoglobins
• Transferrin
• Erythropoietin
• Citric Acid
• ferrous citrate
• Ferritins
• Iron

Topics

• Aged
• Aged, 80 and over
• Anemia, Iron-Deficiency (drug therapy, epidemiology)
• Biomarkers
• Citric Acid
• Erythropoietin
• Female
• Ferritins (blood)
• Ferrous Compounds (administration & dosage, therapeutic use)
• Hematocrit
• Hemoglobins (analysis)
• Humans
• Iron (blood)
• Japan
• Kidney Failure, Chronic (epidemiology, therapy)
• Male
• Middle Aged
• Renal Dialysis (methods)
• Transferrin