Cytoplasmic Lipid Accumulation Characteristic of the Cribriform Variant of Papillary Thyroid Carcinoma.

Abstract

OBJECTIVE:

The purpose of this study was to clarify the diagnostic significance of cytoplasmic lipid accumulation (CLIA) in the cribriform variant of papillary thyroid carcinoma (CV-PTC).

METHODS:

We performed a histological, immunohistochemical, and cytological examination of 35 CV-PTC cases at the Kuma Hospital. CLIA was defined as bubble-like multivacuolation in cytoplasm with distinct cell border. We also examined 100 conventional PTC (con-PTC) cases as controls.

RESULTS:

Histological analysis showed the presence of carcinoma cells with CLIA in 60.0% of CV-PTC and 5.0% of con-PTC cases. The vacuoles tended to distribute in the subnuclear portion of carcinoma cells showing papillary growth. They were positive for oil red O staining and adipophilin. The carcinoma cells without the vacuoles showed a subnuclear dot-like expression for adipophilin in CV-PTC cases, but not in the con-PTC cases. Cytological analysis showed CLIA in 17 (54.8%) of the 31 CV-PTC cases, but not in the con-PTC cases.

CONCLUSION:

This is the first study to report the presence of carcinoma cells with CLIA in CV-PTC. The subnuclear dot-like expression of adipophilin may be characteristic of CV-PTC. These findings might be related to degenerative changes occurring in CV-PTC.

• Authors: Nami Takada, Mitsuyoshi Hirokawa, Aki Ito, Ayana Suzuki, Miyoko Higuchi, Seiji Kuma, Toshitetsu Hayashi, Tsutomu Daa, Akira Miyauchi
• Journal: Pathobiology : journal of immunopathology, molecular and cellular biology (Pathobiology) Vol. 84 Issue 5 Pg. 251-257 ( 2017) ISSN: 1423-0291 [Electronic] Switzerland
• PMID: 28810260 (Publication Type: Journal Article)
• Copyright: © 2017 The Author(s) Published by S. Karger AG, Basel.

Chemical References

• Azo Compounds
• Lipids
• Perilipin-2
• oil red O

Topics

• Adenocarcinoma (diagnosis, pathology)
• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Azo Compounds (chemistry)
• Carcinoma, Papillary (classification, diagnosis, pathology)
• Cytoplasm (chemistry, ultrastructure)
• Female
• Histological Techniques
• Humans
• Immunohistochemistry
• Lipids (physiology)
• Male
• Middle Aged
• Perilipin-2 (chemistry)
• Retrospective Studies
• Thyroid Cancer, Papillary
• Thyroid Neoplasms (classification, diagnosis, pathology)
• Young Adult