Modeling aging in HIV infection in nonhuman primates to address an emerging challenge of the post-ART era.

Abstract

The advent of antiretroviral therapy (ART) has dramatically improved both quality and length of life for subjects infected with human immunodeficiency virus (HIV), delaying or preventing progression to acquired immunodeficiency syndrome (AIDS). However, the virus induces aging-related changes to the immune system which confound treatment. Additionally, the normal physiologic events that occur during aging lead to deficiencies in immunity which not only exacerbate HIV pathogenesis but also trigger a variety of comorbidities. Here, the synergistic linkage between aging and HIV infection is examined in regard to the immunological and pathological mechanisms that drive both senescence and disease progression. The use of NHPs to investigate potential therapeutic strategies to control the deleterious consequences of aging with HIV infection is also reviewed.

• Authors: Tianyu He, Elizabeth Falwell, Egidio Brocca-Cofano, Ivona Pandrea
• Journal: Current opinion in virology (Curr Opin Virol) Vol. 25 Pg. 66-75 (08 2017) ISSN: 1879-6265 [Electronic] Netherlands
• PMID: 28803049 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2017. Published by Elsevier B.V.

Chemical References

• Anti-HIV Agents

Topics

• Aging
• Animals
• Anti-HIV Agents (therapeutic use)
• Antiretroviral Therapy, Highly Active
• Comorbidity
• Disease Models, Animal
• Female
• HIV Infections (drug therapy, immunology, physiopathology)
• HIV-1 (drug effects, immunology)
• Humans
• Inflammation (drug therapy)
• Male
• Primates
• Simian Acquired Immunodeficiency Syndrome (drug therapy, immunology, physiopathology, virology)
• Simian Immunodeficiency Virus (drug effects)