HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Arg913Gln of SLC12A3 gene promotes development and progression of end-stage renal disease in Chinese type 2 diabetes mellitus.

Abstract
Whether the Arg913Gln variation (rs11643718, G/A) of SLC12A3 contributes to diabetic nephropathy (DN) remains controversial. We undertook a case-control study to evaluate the association of the SLC12A3-Arg913Gln variation with the risk of end-stage renal disease (ESRD) in Chinese type 2 diabetes mellitus (T2DM) patients undergoing hemodialysis, and analyzed the genotype-phenotype interaction. Unrelated Chinese T2DM patients (n = 372) with diabetic retinopathy were classified into the non-DN (control) group (n = 151; duration of T2DM >15 years, no signs of renal involvement) and the DN-ESRD group (n = 221; ESRD due to T2DM, receiving hemodialysis). Polymerase chain reaction-direct sequencing was used to genotype the SLC12A3-Arg913Gln variation for all participants. The frequency of the GA+AA genotype in the DN-ESRD group was significantly higher than that of the non-DN group (23.1 vs. 9.9%; adjusted OR 2.2 (95% CI 1.3-4.5), P = 0.019). In the non-DN group, GA+AA carriers had a significantly higher urinary albumin excretion rate (UAER) and diastolic blood pressure compared with GG carriers (both P < 0.05). The SLC12A3-Arg913Gln variation may be associated with increased blood pressure and UAER and, therefore, could be used to predict the development and progression of DN-ESRD in Chinese T2DM patients undergoing hemodialysis.
AuthorsRong Zhang, Langen Zhuang, Ming Li, Juan Zhang, Weijing Zhao, Xiaoxu Ge, Yating Chen, Feng Wang, Niansong Wang, Yuqian Bao, Limei Liu, Yanjun Liu, Weiping Jia
JournalMolecular and cellular biochemistry (Mol Cell Biochem) Vol. 437 Issue 1-2 Pg. 203-210 (Jan 2018) ISSN: 1573-4919 [Electronic] Netherlands
PMID28744814 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • SLC12A3 protein, human
  • Solute Carrier Family 12, Member 3
Topics
  • Aged
  • Amino Acid Substitution
  • Asian People (genetics)
  • China
  • Diabetes Mellitus, Type 2 (genetics, therapy)
  • Diabetic Nephropathies (genetics, therapy)
  • Genotype
  • Humans
  • Kidney Failure, Chronic (genetics, therapy)
  • Middle Aged
  • Mutation, Missense
  • Renal Dialysis
  • Solute Carrier Family 12, Member 3 (genetics)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: