Abstract |
Whether the Arg913Gln variation (rs11643718, G/A) of SLC12A3 contributes to diabetic nephropathy (DN) remains controversial. We undertook a case-control study to evaluate the association of the SLC12A3-Arg913Gln variation with the risk of end-stage renal disease ( ESRD) in Chinese type 2 diabetes mellitus (T2DM) patients undergoing hemodialysis, and analyzed the genotype-phenotype interaction. Unrelated Chinese T2DM patients (n = 372) with diabetic retinopathy were classified into the non-DN (control) group (n = 151; duration of T2DM >15 years, no signs of renal involvement) and the DN- ESRD group (n = 221; ESRD due to T2DM, receiving hemodialysis). Polymerase chain reaction-direct sequencing was used to genotype the SLC12A3-Arg913Gln variation for all participants. The frequency of the GA+AA genotype in the DN- ESRD group was significantly higher than that of the non-DN group (23.1 vs. 9.9%; adjusted OR 2.2 (95% CI 1.3-4.5), P = 0.019). In the non-DN group, GA+AA carriers had a significantly higher urinary albumin excretion rate (UAER) and diastolic blood pressure compared with GG carriers (both P < 0.05). The SLC12A3-Arg913Gln variation may be associated with increased blood pressure and UAER and, therefore, could be used to predict the development and progression of DN- ESRD in Chinese T2DM patients undergoing hemodialysis.
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Authors | Rong Zhang, Langen Zhuang, Ming Li, Juan Zhang, Weijing Zhao, Xiaoxu Ge, Yating Chen, Feng Wang, Niansong Wang, Yuqian Bao, Limei Liu, Yanjun Liu, Weiping Jia |
Journal | Molecular and cellular biochemistry
(Mol Cell Biochem)
Vol. 437
Issue 1-2
Pg. 203-210
(Jan 2018)
ISSN: 1573-4919 [Electronic] Netherlands |
PMID | 28744814
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- SLC12A3 protein, human
- Solute Carrier Family 12, Member 3
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Topics |
- Aged
- Amino Acid Substitution
- Asian People
(genetics)
- China
- Diabetes Mellitus, Type 2
(genetics, therapy)
- Diabetic Nephropathies
(genetics, therapy)
- Genotype
- Humans
- Kidney Failure, Chronic
(genetics, therapy)
- Middle Aged
- Mutation, Missense
- Renal Dialysis
- Solute Carrier Family 12, Member 3
(genetics)
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