A Model for Transfer of P-Glycoproteins in MCF-7 Breast Cancer Cell Line with Multiple Transfer Rules.

Abstract

In this paper, we consider a direct protein transfer process between cells in co-culture. Assuming that cells continually encounter each other, and from some hypotheses on cell-to-cell rules of transfer, we derive discrete and continuous Boltzmann-like integro-differential equations. The novelty of this model is to take into account multiple transfer rules. This new transfer model is used to fit the experimental data of cell-to-cell protein transfer in breast cancer.

• Authors: P Magal, A Noussair, J Pasquier, P Zongo, F Le Foll
• Journal: Bulletin of mathematical biology (Bull Math Biol) Vol. 79 Issue 9 Pg. 2049-2067 (Sep 2017) ISSN: 1522-9602 [Electronic] United States
• PMID: 28721472 (Publication Type: Journal Article)

Chemical References

• ATP Binding Cassette Transporter, Subfamily B
• Neoplasm Proteins

Topics

• ATP Binding Cassette Transporter, Subfamily B (metabolism)
• Breast Neoplasms (drug therapy, metabolism)
• Cell Communication
• Coculture Techniques
• Computer Simulation
• Drug Resistance, Neoplasm
• Female
• Humans
• MCF-7 Cells
• Mathematical Concepts
• Models, Biological
• Neoplasm Proteins (metabolism)
• Protein Transport