Efficacy and Tolerability of a Cosmetic Skin Care Product With Trans-4-t-butylcyclohexanol and Licochalcone A in Subjects With Sensitive Skin Prone to Redness and Rosacea.

Abstract

<p>BACKGROUND: Sensitive skin and rosacea are skin conditions, which may affect the quality of life of the patients considerably. In vitro and in vivo data indicated that the combination of trans-t-butylcyclohexanol and licochalcone A is an effective combination for alleviating the increased sensitivity of rosacea subtype I.</p> <p>OBJECTIVE: Objective of this open dermocosmetic study was to investigate the efficacy and tolerability of a skin care product containing the anti-inflammatory licochalcone A and the TRPV1 antagonist trans-t-butylcyclohexanol in subjects with sensitive skin prone to redness and rosacea.</p> <p>METHODS: 1221 subjects with sensitive skin and rosacea stage 0-II applied the test product twice daily for 4 weeks. Clinical assessment of sensitive skin and rosacea symptoms were performed at baseline and after 4 weeks. Additionally, at treatment end the test subjects filled a self-assessment questionnaire.</p> <p>RESULTS: After 4 weeks of application, both, clinical and subjective assessment have shown improvement of all symptoms of sensitive skin and rosacea in a significant number of subjects (P less than 0.001). The test product was efficacious and very well tolerated also when used in conjunction with pharmacological treatments of the skin condition under scrutiny.</p> <p>Conclusions: The study confirmed the good tolerability and efficacy of the skin care product in the management of sensitive skin prone to redness and rosacea when used alone or in combination with other therapies.</p> <p><em>J Drugs Dermatol. 2017;16(6):605-611.</em></p>.

• Authors: Zorica Jovanovic, Nariman Angabini, Sonja Ehlen, Zrinka Bukvic Mokos, Milica Subotic, Gitta Neufang
• Journal: Journal of drugs in dermatology : JDD (J Drugs Dermatol) Vol. 16 Issue 6 Pg. 605-610 (Jun 01 2017) ISSN: 1545-9616 [Print] United States
• PMID: 28686779 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Chalcones
• Cosmetics
• Cyclohexanols
• Dermatologic Agents
• Drug Combinations
• TRPV Cation Channels
• TRPV1 protein, human
• licochalcone A
• 4-tert-butylcyclohexanol

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, therapeutic use)
• Chalcones (adverse effects, therapeutic use)
• Cosmetics (adverse effects, therapeutic use)
• Cyclohexanols (adverse effects, therapeutic use)
• Dermatologic Agents (adverse effects, therapeutic use)
• Drug Combinations
• Female
• Humans
• Male
• Middle Aged
• Patient Satisfaction
• Prospective Studies
• Rosacea (drug therapy, pathology)
• Skin Care
• Skin Diseases (drug therapy)
• TRPV Cation Channels (antagonists & inhibitors)
• Treatment Outcome
• Young Adult