Predictors and Clinical Impact of Functional Mitral Stenosis Induced by Restrictive Annuloplasty for Ischemic and Functional Mitral Regurgitation.

Abstract

BACKGROUND:

There are few reports of the determinants of "functional" mitral stenosis in terms of a residual mitral valve (MV) pressure gradient >5 mmHg following restrictive mitral annuloplasty (RMA) or the effect on long-term outcome in patients with functional mitral regurgitation (MR).Methods and Results:Serial cardiac catheterization and echocardiographic studies were performed in 55 patients with functional MR who underwent RMA using a 24/26-mm semi-rigid complete ring. The mean postoperative (1 month) catheter-measured MV gradient was 3.4±1.6 mmHg, which was independently associated with corresponding cardiac output [standardized partial regression coefficient (SPRC)=0.59] and indexed effective orifice area (SPRC=-0.25). Body surface area (BSA) had the greatest contribution to MV gradient (SPRC=0.38), followed by use of a 24-mm ring (SPRC=0.33) and hemodialysis (SPRC=0.26). Receiver-operating characteristic curve analysis demonstrated an optimal BSA cutoff value of 1.86 m2to predict post-MV stenosis (21% for <1.86 m2vs. 86% for ≥1.86 m2, P=0.002). During follow-up (75±32 months), freedom from adverse events did not differ between patients with (n=16) and without (n=39) an MV gradient ≥5 mmHg (log-rank P=0.24).

CONCLUSIONS:

Post-RMA MV gradient was determined not only by the degree of annular reduction but also by patients' hemodynamic factors (e.g., cardiac output). Implantation of a 24/26-mm annuloplasty ring for patients with BSA ≥1.86 m2indicated a high likelihood of post-MV stenosis. However, mild MV stenosis did not adversely affect late outcome after RMA.

• Authors: Satoshi Kainuma, Kazuhiro Taniguchi, Koichi Toda, Toshihiro Funatsu, Haruhiko Kondoh, Shigeru Miyagawa, Yasushi Yoshikawa, Hiroki Hata, Shunsuke Saito, Takayoshi Ueno, Toru Kuratani, Takashi Daimon, Takafumi Masai, Yoshiki Sawa, Osaka Cardiovascular Surgery Research (OSCAR) Group
• Journal: Circulation journal : official journal of the Japanese Circulation Society (Circ J) Vol. 81 Issue 12 Pg. 1832-1838 (Nov 24 2017) ISSN: 1347-4820 [Electronic] Japan
• PMID: 28659549 (Publication Type: Journal Article)

Topics

• Aged
• Cardiac Catheterization
• Female
• Hemodynamics
• Humans
• Male
• Middle Aged
• Mitral Valve Annuloplasty (adverse effects)
• Mitral Valve Insufficiency (therapy)
• Mitral Valve Stenosis (etiology)
• Myocardial Ischemia
• Treatment Outcome