Abstract | INTRODUCTION: METHODS: POEMS and CIDP patients who had undergone NCS and blink reflex were identified. Correlations among R1 latency, limb NCS, and neuropathy impairment scores (NIS) were compared. RESULTS: Among 182 patients (124 POEMS, 58 CIDP) who were identified, R1 prolongation (>13 ms) occurred in 64.3% (65.3% POEMS, 62.1% CIDP). R1 prolongation correlated with more severely affected NCS in both POEMS (ulnar CMAP 2.6 mV vs. 4.5 mV, P = 0.001) and CIDP (2.0 mV vs. 6.1 mV, P < 0.001). In severely affected patients (ulnar CMAP ≤0.5 mV [10%:18/182]), R1 (>13 ms) helped establish demyelination. In 31 patients (16 POEMS, 15 CIDP), the R1 latency changes were concordant with NIS changes in 94% of patients with POEMS and 60% of patients with CIDP. DISCUSSION: Blink R1 latencies are valuable in defining demyelination and detecting improvement in severely affected POEMS and CIDP patients. Muscle Nerve 57: E8-E13, 2018.
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Authors | Wei Wang, William J Litchy, Michelle L Mauermann, P James B Dyck, Angela Dispenzieri, Jay Mandrekar, Peter J Dyck, Christopher J Klein |
Journal | Muscle & nerve
(Muscle Nerve)
Vol. 57
Issue 1
Pg. E8-E13
(Jan 2018)
ISSN: 1097-4598 [Electronic] United States |
PMID | 28646568
(Publication Type: Journal Article)
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Copyright | © 2017 Wiley Periodicals, Inc. |
Topics |
- Adult
- Blinking
- Diagnosis, Differential
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Nervous System Diseases
(etiology, physiopathology)
- Neural Conduction
- Neurologic Examination
- POEMS Syndrome
(diagnosis, physiopathology, therapy)
- Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
(diagnosis, physiopathology, therapy)
- Reproducibility of Results
- Retrospective Studies
- Stem Cell Transplantation
- Treatment Outcome
- Ulnar Nerve
(physiopathology)
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