Efficacy and safety of conbercept as a primary treatment for choroidal neovascularization secondary to punctate inner choroidopathy.

Abstract

BACKGROUND:

To evaluate the efficacy and safety of intravitreal conbercept (KH902) as the primary treatment of choroidal neovascularization secondary to punctate inner choroidopathy.

METHODS:

This study was a retrospective, consecutive, observational case series. We reviewed medical records of 16 eyes (16 patients) with naive subfoveal or juxtafoveal choroidal neovascularization secondary to punctuate inner choroidopathy that were treated with intravitreal conbercept injections. All patients completed at least six months of follow-up. Best-corrected visual acuity (BCVA) was measured, and anatomical features were assessed with fluorescein angiography, indocyanine green angiography, and optical coherence tomography.

RESULTS:

At the month-6 follow-up visit, best-corrected visual acuity improved from 0.70 ± 0.36 (with approximate Snellen equivalent of 20/100) to 0.44 ± 0.25 (20/50 in Snellen) logarithm of the minimum angle of resolution (logMAR) (P = 0.003). Mean improvement of vision was 2.6 lines, with 50% treated eyes (8 eyes of 16) showing an improvement of ≥3 lines and 62.5% (10 eyes of 16), obtaining an improvement of ≥2 lines; all 16 eyes had stable or improved vision. Mean central retinal thickness decreased from 294.94 ± 102.68 μm to 206.56 ± 61.71 μm (P = 0.005). Fifteen eyes (93.75%) showed absence of CNV leakage at the end of the study period. No conbercrept-related systemic or ocular adverse events were observed.

CONCLUSION:

Intravitreal injection of conbercept significantly improved visual and anatomical outcomes in choroidal neovascularization secondary to punctate inner choroidopathy over a 6-month follow-up period.

TRIAL REGISTRATION:

ISRCTN85678307 , retrospectively registered on May 11, 2017.

• Authors: Yuting Peng, Xiongze Zhang, Lan Mi, Bing Liu, Chengguo Zuo, Miaoling Li, Feng Wen
• Journal: BMC ophthalmology (BMC Ophthalmol) Vol. 17 Issue 1 Pg. 87 (Jun 12 2017) ISSN: 1471-2415 [Electronic] England
• PMID: 28606070 (Publication Type: Journal Article, Observational Study)

Chemical References

• Recombinant Fusion Proteins
• KH902 fusion protein

Topics

• Adult
• Aged
• Choroid (pathology)
• Choroidal Neovascularization (diagnosis, drug therapy, etiology)
• Choroiditis (complications, diagnosis, drug therapy)
• Female
• Fluorescein Angiography
• Follow-Up Studies
• Fundus Oculi
• Humans
• Intravitreal Injections
• Male
• Middle Aged
• Multifocal Choroiditis
• Recombinant Fusion Proteins (administration & dosage)
• Retrospective Studies
• Time Factors
• Tomography, Optical Coherence
• Treatment Outcome
• Visual Acuity