HLA-A*31: 01 and HLA-B*15:02 association with Stevens-Johnson syndrome and toxic epidermal necrolysis to carbamazepine in a multiethnic Malaysian population.

HLA-A31: 01 and HLA-B15:02 association with Stevens-Johnson syndrome and toxic epidermal necrolysis to carbamazepine in a multiethnic Malaysian population.

Abstract	The majority of the carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis CBZ-SJS/TEN are associated with HLA-B15:02 in Asian populations where this allele is common. In contrast, the association with HLA-A31:01 is only reported in Japanese and Europeans. This study aimed to further investigate the association with HLA-A31:01 besides HLA-B15:02 in a multiethnic Malaysian population. Twenty-eight CBZ-SJS/TEN cases and 227 CBZ-tolerant controls were recruited. Association was tested by comparing carrier frequencies of the alleles between cases and controls. Significant associations were detected between HLA-B15:02 and CBZ-SJS/TEN in independent ethnic groups: Malays [P=2.00×10; odds ratio (OR): 49.0; 95% confidence interval (CI): 9.36-256.81], Chinese (P=0.0047; OR: 14.3; 95% CI: 2.38-86.03) and Indians (P=0.04; OR: 13.8; 95% CI: 1.51-124.99). Combined analysis of all ethnic groups showed a significant association with OR Cochran-Mantel-Haenszel (ORCMH) of 26.6 (95% CI: 12.80-55.25; PCMH=2.31×10). In Indians, HLA-A31:01 was found to be associated significantly with CBZ-SJS/TEN (P=0.023; OR: 10.4; 95% CI: 1.64-65.79) and combined analyses of both variants, HLA-A31:01 and HLA-B15:02, increased the strength of the association (P=0.0068; OR: 14.3; 95% CI: 2.20-92.9). Besides HLA-B15:02, our study found a new association between HLA-A31:01 and CBZ-SJS/TEN in Indians.
Authors	Amy Hui-Ping Khor, Kheng-Seang Lim, Chong-Tin Tan, Zhenli Kwan, Wooi-Chiang Tan, David Bin-Chia Wu, Ching-Ching Ng
Journal	Pharmacogenetics and genomics (Pharmacogenet Genomics) Vol. 27 Issue 7 Pg. 275-278 (07 2017) ISSN: 1744-6880 [Electronic] United States
PMID	28570299 (Publication Type: Journal Article)
Chemical References	HLA-A Antigens HLA-B Antigens Carbamazepine
Topics	Adolescent Adult Aged Alleles Asian People (genetics) Carbamazepine (adverse effects) Case-Control Studies Child Ethnicity (genetics) Female HLA-A Antigens (genetics) HLA-B Antigens (genetics) Humans Malaysia Male Middle Aged Stevens-Johnson Syndrome (etiology, genetics) Young Adult

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