Occupational and life-style factors-acquired mutagenicity in agric-workers of northeastern Brazil.

Abstract

Pesticides are a complex mixture of chemicals used to protect crops from a number of pests and diseases. They have been considered as potential mutagenic agents. This study aims at evaluation of the mutagenic effect of pesticide exposure to agricultural workers through chromosomal aberrations (CA) and micronucleus (MN) assay in peripheral blood lymphocytes and oral mucosal cells, respectively. The exposed group was consisted with 97 farmers, while the control (un-exposed) group consisted of 55. The results showed a significant (p < 0.05) increase in frequency of CA and MN in the exposed group. Both CA and MN profiles were linked to a significant (p < 0.05) co-relation with the confounding factors such as smoking habits, alcohol, vegetables, tea/coffee, vitamins, and sweetener consumptions. More cytogenetic events were denoted in smoking and alcohol consumption as well as non-personal protective equipment (non-PPE) and low/no vegetables user farmers. In conclusion, a deficiency of dietary and medicaments-derived antioxidants, while consumption of alcohol and tobacco, as well as effects of radiation, heavy metal poisoning (especially from sweeteners), and non-PPE using habits, may contribute cytogenetic damage to the workers.

• Authors: Tatiana Vieira Souza Chaves, Muhammad Torequl Islam, Manoel Odoríco de Moraes, Marcus Vinícius Oliveira Barros de Alencar, Débora Cássia Vieira Gomes, Rodrigo Mendes de Carvalho, Sharbel Weider Maluf, Fabrício Pires de Moura do Amaral, Márcia Fernanda Correia Jardim Paz, Gilberto Santos Cerqueira, Hercília Maria Lins Rolim, João Marcelo de Castro E Sousa, Ana Amélia de Carvalho Melo-Cavalcante, Maria Elisabete Amaral de Moraes
• Journal: Environmental science and pollution research international (Environ Sci Pollut Res Int) Vol. 24 Issue 18 Pg. 15454-15461 (Jun 2017) ISSN: 1614-7499 [Electronic] Germany
• PMID: 28510803 (Publication Type: Journal Article)

Chemical References

• Mutagens
• Pesticides

Topics

• Adolescent
• Adult
• Aged
• Alcohol Drinking
• Brazil
• Chromosome Aberrations
• DNA Damage
• Diet
• Farmers
• Humans
• Life Style
• Lymphocytes
• Male
• Micronucleus Tests
• Middle Aged
• Mutagens (toxicity)
• Occupational Exposure
• Pesticides (toxicity)
• Smoking
• Young Adult