Inhibition of mast cell infiltration in an LL-37-induced rosacea mouse model using topical brimonidine tartrate 0.33% gel.

Abstract

Brimonidine is a highly selective α2-adrenergic receptor agonist approved by the FDA for the treatment of rosacea. Rosacea is a major clinical disease with vasodilatation and rash on the centre of the face, and that brimonidine as a vasoconstrictor can act as a remedy for rosacea. However, there is no study of how brimonidine has an effect on rosacea-related immune cells or mechanisms in the skin to improve rosacea. In this study, we observed that clinical features of rosacea induced by LL-37 in Balb/c mice were improved after the application of brimonidine gel, and we also showed a marked decrease in the number of inflammatory cells, especially mast cells (MCs) histologically. Furthermore, we confirmed that mRNA levels of MC enzymes increased by LL-37 were reduced by brimonidine gel. To our knowledge, we first found that brimonidine has a mechanism of treating rosacea by reducing the number and mRNA levels of MC-specific enzymes, an important immune cell in the pathogenesis of rosacea.

• Authors: Miri Kim, Jongsic Kim, Seo-Won Jeong, Hyunmu Jo, Yu Ri Woo, Hyun Jeong Park
• Journal: Experimental dermatology (Exp Dermatol) Vol. 26 Issue 11 Pg. 1143-1145 (11 2017) ISSN: 1600-0625 [Electronic] Denmark
• PMID: 28500634 (Publication Type: Letter)
• Copyright: © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Adrenergic alpha-2 Receptor Agonists
• Antimicrobial Cationic Peptides
• Enzymes
• Gels
• RNA, Messenger
• Brimonidine Tartrate
• Cathelicidins

Topics

• Administration, Cutaneous
• Adrenergic alpha-2 Receptor Agonists (administration & dosage, therapeutic use)
• Animals
• Antimicrobial Cationic Peptides
• Brimonidine Tartrate (administration & dosage, therapeutic use)
• Cell Movement (drug effects)
• Disease Models, Animal
• Enzyme Induction (drug effects)
• Enzymes (genetics)
• Female
• Gels
• Mast Cells (enzymology, physiology)
• Mice
• RNA, Messenger (metabolism)
• Rosacea (chemically induced, drug therapy, enzymology, pathology)
• Cathelicidins