Abstract | PURPOSE: METHODS AND MATERIALS: Single-arm phase 1/2 study of previously untreated patients with biopsy-proven SCC of the oropharynx, larynx, or hypopharynx. The primary endpoint was feasibility of the regimen, defined as the proportion of patients successfully completing treatment. Secondary endpoints were locoregional control (LRC), failure-free survival (FFS), overall survival (OS), and treatment toxicities. RESULTS: Sixty patients were included in the study. Their mean age was 66 years (range, 42-87 years); 28% of patients were >70 years. The median follow-up time was 4 years. Compliance with treatment was very high: feasibility was 55/60 (91.7%, 90% CI: 83.3%-96.7%), which satisfied the predefined criteria. The 4-year LRC was 82% (95% CI: 71-94), the FFS was 72% (95% CI: 60-85), and the OS was 77% (95% CI: 66-90). The cumulative incidences of first failure of any type at 4 years were 5.2% local, 1.8% local and distant, 8.5% regional, 1.7% regional and distant, 3.5% distant, and 7.7% death (any cause). The 4-year FFS in the patients aged ≤70 years and >70 years were 71% (95% CI: 58-88) and 73% (95% CI: 54-100), respectively (log-rank P=.801). Their 4-year OS was 79% (95% CI: 66-93) and 73% (95% CI: 53-100), respectively (log-rank P=.708). Significant late treatment toxicities were very few. CONCLUSION:
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Authors | June Corry, Mathias Bressel, Tsien Fua, Alan Herschtal, Benjamin Solomon, Sandro V Porceddu, Chris Wratten, Danny Rischin |
Journal | International journal of radiation oncology, biology, physics
(Int J Radiat Oncol Biol Phys)
Vol. 98
Issue 4
Pg. 948-954
(07 15 2017)
ISSN: 1879-355X [Electronic] United States |
PMID | 28483336
(Publication Type: Clinical Trial, Phase I, Clinical Trial, Phase II, Journal Article)
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Copyright | Copyright © 2017 Elsevier Inc. All rights reserved. |
Chemical References |
- Antineoplastic Agents
- Carboplatin
- Cetuximab
- Cisplatin
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Antineoplastic Agents
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Carboplatin
(administration & dosage)
- Carcinoma, Squamous Cell
(mortality, pathology, therapy)
- Cetuximab
(administration & dosage)
- Chemoradiotherapy
(methods)
- Cisplatin
- Contraindications
- Disease-Free Survival
- Dose Fractionation, Radiation
- Drug Administration Schedule
- Feasibility Studies
- Follow-Up Studies
- Head and Neck Neoplasms
(mortality, pathology, therapy)
- Humans
- Hypopharyngeal Neoplasms
(mortality, pathology, therapy)
- Laryngeal Neoplasms
(mortality, pathology, therapy)
- Middle Aged
- Oropharyngeal Neoplasms
(mortality, pathology, therapy)
- Prospective Studies
- Time Factors
- Treatment Outcome
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