New Macrolide-Lincosamide-Streptogramin B Resistance Gene erm(48) on the Novel Plasmid pJW2311 in Staphylococcus xylosus.

Abstract

Whole-genome sequencing of Staphylococcus xylosus strain JW2311 from bovine mastitis milk identified the novel 49.3-kb macrolide-lincosamide-streptogramin B (MLSB) resistance plasmid pJW2311. It contained the macrolide resistance gene mph(C), the macrolide-streptogramin B resistance gene msr(A), and the new MLSB resistance gene erm(48) and could be transformed into Staphylococcus aureus by electroporation. Functionality of erm(48) was demonstrated by cloning and expression in S. aureus.

• Authors: Juliette R K Wipf, Matthew C Riley, Stephen A Kania, David A Bemis, Sabrina Andreis, Sybille Schwendener, Vincent Perreten
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 61 Issue 7 (07 2017) ISSN: 1098-6596 [Electronic] United States
• PMID: 28438941 (Publication Type: Journal Article)
• Copyright: Copyright © 2017 American Society for Microbiology.

Chemical References

• Anti-Bacterial Agents
• Bacterial Proteins
• Lincosamides
• Macrolides
• Streptogramin B

Topics

• Anti-Bacterial Agents (pharmacology)
• Bacterial Proteins (genetics, metabolism)
• Drug Resistance, Multiple, Bacterial (genetics)
• Lincosamides (pharmacology)
• Macrolides (pharmacology)
• Microbial Sensitivity Tests
• Plasmids (genetics)
• Staphylococcus (drug effects)
• Streptogramin B (pharmacology)