Abstract | BACKGROUND: METHODS: The Medline, EMBASE, and Cochrane databases were searched for randomized clinical trials confirming the effects of PGE1. Two investigators independently selected suitable trials, assessed trial quality, and extracted data. RESULTS: Six studies in patients undergoing percutaneous coronary intervention (4 studies) and cardiac surgery (2 studies), comprising a total of 445 patients, were included in this review. The results showed that PGE1 reduced the incidence of CRIE (relative ratio 0.4 [95% confidence interval 0.43, 0.95]), the incidence of MACE (0.35 [0.17, 0.70]), and the level of troponin T (standardized mean difference 20.28 [20.47, 20.09]), creatine kinase-MB (-1.74 [-3.21, - 0.27]), interleukin-6 (-1.37 [-2.69, - 0.04]), and interleukin-8 (-2.05 [-2.75, - 1.34]). CONCLUSION:
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Authors | Houyong Zhu, Xiaoqun Xu, Yu Ding, Liang Zhou, Jinyu Huang |
Journal | Medicine
(Medicine (Baltimore))
Vol. 96
Issue 15
Pg. e6591
(Apr 2017)
ISSN: 1536-5964 [Electronic] United States |
PMID | 28403095
(Publication Type: Journal Article, Meta-Analysis)
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Chemical References |
- Biomarkers
- CXCL8 protein, human
- Cardiotonic Agents
- IL6 protein, human
- Interleukin-6
- Interleukin-8
- Troponin T
- Creatine Kinase, MB Form
- Alprostadil
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Topics |
- Aged
- Alprostadil
(administration & dosage)
- Biomarkers
(blood)
- Cardiac Surgical Procedures
(adverse effects, methods)
- Cardiotonic Agents
(administration & dosage)
- Creatine Kinase, MB Form
(blood)
- Female
- Humans
- Incidence
- Interleukin-6
(blood)
- Interleukin-8
(blood)
- Male
- Middle Aged
- Myocardial Reperfusion Injury
(epidemiology, etiology, prevention & control)
- Percutaneous Coronary Intervention
(adverse effects, methods)
- Postoperative Period
- Randomized Controlled Trials as Topic
- Troponin T
(blood)
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