Ocular Involvement in Children with Inflammatory Bowel Disease.

Abstract

BACKGROUND:

Data on ocular manifestations of inflammatory bowel disease (IBD) in children are limited. Some authors have reported a high prevalence of asymptomatic uveitis, yet the significance of these observations is unknown and there are no recommendations on which ophthalmologic follow-up should be offered.

METHODS:

Children with IBD seen at a single referral center for pediatric gastroenterology were offered ophthalmologic evaluation as part of routine care for their disease. Ophthalmologic evaluation included review of ocular history as well as slit-lamp and fundoscopic examination. Medical records were also reviewed for previous ophthalmologic diagnoses or complaints.

RESULTS:

Data from 94 children were included (52 boys; median age 13.4 yr). Forty-six patients had a diagnosis of Crohn's disease, 46 ulcerative colitis, and 2 IBD unclassified. Intestinal disease was in clinical remission in 70% of the patients; fecal calprotectin was elevated in 64%. One patient with Crohn's disease had a previous diagnosis of clinically manifest uveitis (overall uveitis prevalence: 1.06%; incidence rate: 0.3 per 100 patient-years). This patient was also the only one who was found to have asymptomatic uveitis at slit-lamp examination. A second patient had posterior subcapsular cataract associated with corticosteroid treatment. No signs of intraocular complications from previous unrecognized uveitis were observed in any patient.

CONCLUSIONS:

Children with IBD may have asymptomatic uveitis, yet its prevalence seems lower than previously reported, and it was not found in children without a previous diagnosis of clinically manifest uveitis. No ocular complications from prior unrecognized uveitis were observed.

• Authors: Samuele Naviglio, Fulvio Parentin, Silvia Nider, Nicolò Rassu, Stefano Martelossi, Alessandro Ventura
• Journal: Inflammatory bowel diseases (Inflamm Bowel Dis) Vol. 23 Issue 6 Pg. 986-990 (06 2017) ISSN: 1536-4844 [Electronic] England
• PMID: 28328621 (Publication Type: Journal Article)

Chemical References

• Leukocyte L1 Antigen Complex

Topics

• Adolescent
• Child
• Child, Preschool
• Feces (chemistry)
• Female
• Humans
• Inflammatory Bowel Diseases (complications)
• Italy (epidemiology)
• Leukocyte L1 Antigen Complex (analysis)
• Male
• Remission Induction
• Uveitis (epidemiology)