Abstract | BACKGROUND: METHODS: Injection of vincristine (0.1 mg · kg · day, intraperitoneally, for 10 days) was used to induce nociceptive sensitization, which was accessed with von Frey hairs and the plantar tester in adult male Sprague-Dawley rats. Magnesium-L- threonate was administered through drinking water (604 mg · kg · day). Extracellular and intracellular free Mg were measured by Calmagite chromometry and flow cytometry. Molecular biologic and electrophysiologic experiments were performed to expose the underlying mechanisms. RESULTS: CONCLUSIONS:
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Authors | Ting Xu, Dai Li, Xin Zhou, Han-Dong Ouyang, Li-Jun Zhou, Hang Zhou, Hong-Mei Zhang, Xu-Hong Wei, Guosong Liu, Xian-Guo Liu |
Journal | Anesthesiology
(Anesthesiology)
Vol. 126
Issue 6
Pg. 1151-1168
(06 2017)
ISSN: 1528-1175 [Electronic] United States |
PMID | 28306698
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Butyrates
- NF-kappa B
- Tumor Necrosis Factor-alpha
- Vincristine
- threonic acid
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Topics |
- Administration, Oral
- Animals
- Antineoplastic Agents, Phytogenic
- Butyrates
(administration & dosage, pharmacology)
- Disease Models, Animal
- Hyperalgesia
(chemically induced, drug therapy)
- Male
- NF-kappa B
(drug effects)
- Rats
- Rats, Sprague-Dawley
- Signal Transduction
(drug effects)
- Tumor Necrosis Factor-alpha
(drug effects)
- Vincristine
(adverse effects)
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