Effects of Remineralization Agents on Artificial Carious Lesions.

Abstract

PURPOSE:

The purpose of this study was to evaluate the remineralization potentials of different agents on demineralized enamel surfaces.

METHODS:

Four hundred and sixty extracted human molars with artificial carious lesions were divided into six groups: (1) control; (2) acidulated phosphate fluoride (APF); (3) Curodont Repair (CR); (4) silver diamine fluoride (SDF); (5) ammonium hexafluorosilicate (SiF); and (6) SiF plus cetylpiridinium chloride (SiF+CPC). They were subdivided according to immersion periods (seven out of 30 days). After demineralization and remineralization procedures, microhardness test (VHN), energy-dispersive X-ray spectroscopy analysis, and confocal laser scanning microscopy evaluation were performed. The data were statistically analyzed.

RESULTS:

By the 30-day remineralization, the mean differences in VHN values were ranked as follows, in order: (1) CR; (2) APF; (3) SiF; (4) SiF+CPC; (5) SDF; and (6) control (P<0.05). The calcium (Ca) content and calcium/phosphate ratio for all groups were significantly higher after 30 days (P<0.05). The greatest lesion depth changes were observed in the CR, APF, SiF, and SDF groups (P<0.05), while the greatest fluorescence changes were observed in the APF, SiF, and CR groups (P<0.05).

CONCLUSIONS:

The remineralization was most successful in the CR, APF, and SiF groups, with higher values than for those of the other treatments.

• Authors: Selcuk Savas, Ebru Kucukyilmaz, Esra Uzer Celik
• Journal: Pediatric dentistry (Pediatr Dent) Vol. 38 Issue 7 Pg. 511-518 (Nov 15 2016) ISSN: 1942-5473 [Electronic] United States
• PMID: 28281957 (Publication Type: Journal Article)

Chemical References

• Cariostatic Agents
• Fluorides, Topical
• Phosphates
• Quaternary Ammonium Compounds
• Silver Compounds
• Silicic Acid
• hexafluorosilicate
• Acidulated Phosphate Fluoride
• Cetylpyridinium
• silver diamine fluoride
• Fluorides
• Calcium

Topics

• Acidulated Phosphate Fluoride (pharmacology)
• Administration, Topical
• Calcium (analysis)
• Cariostatic Agents (pharmacology)
• Cetylpyridinium (pharmacology)
• Dental Caries
• Dental Enamel (drug effects)
• Fluorides (pharmacology)
• Fluorides, Topical (pharmacology)
• Hardness
• Humans
• Materials Testing
• Microscopy, Confocal
• Molar (drug effects)
• Phosphates (analysis)
• Quaternary Ammonium Compounds (pharmacology)
• Silicic Acid (pharmacology)
• Silver Compounds
• Surface Properties (drug effects)
• Time Factors
• Tooth Demineralization
• Tooth Remineralization (methods)