Abstract |
A 3,200 g birth weight, 38-week gestational age neonate developed very severe persistent pulmonary hypertension following surgical repair of a left diaphragmatic hernia. Despite administration of dopamine, dobutamine, and tolazoline, a significant alveolar-arterial oxygen difference (660 mmHg) was found at age 41 hours. Nifedipine was then administered sublingually in a dose of 1 mg/kg and produced an immediate and dramatic improvement in the right radial artery pO2 that was sustained despite persistence of the right-to-left shunt. We discuss the mode of action of this vasodilating agent that, when added to major therapeutic agents, proved capable of completely reversing a hazardous neonatal situation.
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Authors | A Burguet, A Menget, C Fromentin, R Destuynder |
Journal | Annales de pediatrie
(Ann Pediatr (Paris))
Vol. 36
Issue 8
Pg. 557-9
(Oct 1989)
ISSN: 0066-2097 [Print] France |
Vernacular Title | Efficacité de la nifédipine sur l'hypoxémie réfractaire associée à la hernie diaphragmatique du nouveau-né. A propos d'une observation. |
PMID | 2817706
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Drug Evaluation
- Hernia, Diaphragmatic
(surgery)
- Hernias, Diaphragmatic, Congenital
- Humans
- Hypertension, Pulmonary
(drug therapy, etiology)
- Hypoxia
(drug therapy, etiology)
- Infant, Newborn
- Male
- Nifedipine
(therapeutic use)
- Postoperative Complications
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