Chitosan coated tungsten trioxide nanoparticles as a contrast agent for X-ray computed tomography.

Abstract

Recent advances have shown that inorganic nanoparticles (NPs) based on heavy elements are highly appropriate for X-ray computed tomography (CT). In this contribution, tungsten trioxide NPs are prepared by the electrical arc discharge (EAD) method in DI water. The effect of chitosan (CTS) and glutaraldehyde (GTA) as coating and cross-linking agent, respectively, on the hydrodynamic size and zeta potential of prepared tungsten trioxide NPs is investigated. It is found that zeta potential increases by increasing the amounts of CTS. Meanwhile, by increasing the volume of glutaraldehyde (GTA), the final particle size increases whereas the zeta potential deceases. Chitosan coated tungsten trioxide demonstrated no significant cytotoxicity at concentration up to 5mg/mL after 24h. Finally, the X-ray attenuation of prepared chitosan coated tungsten trioxide NPs are higher than Iohexol as the commercially available iodinated contrasting agent at the same concentrations.

• Authors: Mehdi Firouzi, Reza Poursalehi, Hamid Delavari H, Fakhredin Saba, Mohammad A Oghabian
• Journal: International journal of biological macromolecules (Int J Biol Macromol) Vol. 98 Pg. 479-485 (May 2017) ISSN: 1879-0003 [Electronic] Netherlands
• PMID: 28174086 (Publication Type: Journal Article)
• Copyright: Copyright © 2017 Elsevier B.V. All rights reserved.

Chemical References

• Contrast Media
• Oxides
• Chitosan
• tungsten oxide
• Tungsten

Topics

• Cell Line, Tumor
• Cell Survival (drug effects)
• Chitosan (chemistry)
• Contrast Media (chemistry, toxicity)
• Humans
• Nanoparticles
• Oxides (chemistry, toxicity)
• Particle Size
• Tomography, X-Ray Computed
• Tungsten (chemistry, toxicity)