Abstract | BACKGROUND: METHODS: We trained male rats to drink EtOH using the intermittent access 20% EtOH 2-bottle free-choice drinking paradigm for 8 weeks, after which the alcohol supply was discontinued. We measured pain sensitivity using radiant heat (a light beam directed at the hind paw of rats) and compared the paw withdrawal latencies (PWLs) with and without EA at ST36. RESULTS: The PWLs were significantly shorter in rats at 24, 48, and 72 hours and 7 days after the discontinuation of EtOH when compared to EtOH-naïve rats. After a single administration of 2-Hz EA for 20 minutes at ST36, the PWLs at 24 hours after the withdrawal of EtOH were significantly greater than those of the sham group (2-Hz EA at the tail). Furthermore, the effect of EA on PWLs was significantly attenuated by bilateral intrahabenula infusion of the MOR antagonist naltrexone. CONCLUSIONS:
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Authors | Jing Li, Caihong Fu, Hongwei Liu, Rao Fu, Wanhong Zuo, Seungwoo Kang, Pei Chen, Danielle Gregor, Rose Paulose, Alex Bekker, Jiang-Hong Ye |
Journal | Alcoholism, clinical and experimental research
(Alcohol Clin Exp Res)
Vol. 41
Issue 3
Pg. 637-643
(03 2017)
ISSN: 1530-0277 [Electronic] England |
PMID | 28166603
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2017 by the Research Society on Alcoholism. |
Chemical References |
- Narcotic Antagonists
- Receptors, Opioid, mu
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Topics |
- Alcohol Drinking
(adverse effects, therapy)
- Alcoholism
(complications, therapy)
- Animals
- Electroacupuncture
(methods)
- Habenula
(drug effects, physiology)
- Hyperalgesia
(etiology, prevention & control)
- Male
- Microinjections
- Narcotic Antagonists
(administration & dosage)
- Rats
- Rats, Long-Evans
- Receptors, Opioid, mu
(antagonists & inhibitors, physiology)
- Substance Withdrawal Syndrome
(etiology, therapy)
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