Abstract | PURPOSE: METHODS: The choriocapillaris under the central macula was imaged with the Optovue RTVue XR Avanti using a 10 μm slab thickness. Automatic local thresholding of the resultant raw data extracted areas of absent flow signal, called signal voids, and these were counted and logarithmically binned. The signal void patterns were analyzed in four eyes of two patients with maternally inherited diabetes and deafness and four eyes of three patients with pseudoxanthoma elasticum. None of the patients had geographic atrophy. These data were compared with 55 eyes of 38 healthy control subjects and analyzed with generalized estimating equations. RESULTS: The choriocapillaris images in maternally inherited diabetes and deafness and pseudoxanthoma elasticum show that the model of signal voids followed a power law distribution, but with a slope and offset much lower than the normal control group, adjusted for age (P < 0.001). The eyes in the disease group were much more likely to have signal voids greater than 40,000 μm. CONCLUSION:
|
Authors | Richard F Spaide |
Journal | Retina (Philadelphia, Pa.)
(Retina)
Vol. 37
Issue 11
Pg. 2008-2014
(Nov 2017)
ISSN: 1539-2864 [Electronic] United States |
PMID | 28092344
(Publication Type: Journal Article)
|
Topics |
- Capillaries
(diagnostic imaging, physiopathology)
- Choroid
(blood supply)
- Deafness
(diagnosis, physiopathology)
- Diabetes Mellitus, Type 2
(diagnosis, physiopathology)
- Disease Progression
- Female
- Fluorescein Angiography
(methods)
- Follow-Up Studies
- Fundus Oculi
- Humans
- Male
- Middle Aged
- Mitochondrial Diseases
(diagnosis, physiopathology)
- Pseudoxanthoma Elasticum
(diagnosis, physiopathology)
- Retinal Pigment Epithelium
- Retrospective Studies
- Tomography, Optical Coherence
(methods)
- Visual Acuity
|