[Effectiveness of INH-rifampicin treatment of lymph node tuberculosis].

Abstract

The efficacy of the therapy of tuberculous lymphadenitis using two drugs with bactericidal activity is described. In this localization, the tuberculous process implies tubercle bacilli only in limited quantity, and thus, in contrast to the requirements and recommendations for the treatment of pulmonary tuberculosis, the application of only two drugs with bactericidal activity is sufficient. The treatment of 128 patients with histologically confirmed tuberculous lymphadenitis consisted in daily application of isoniazid and rifampicin during 4 to 6 weeks, followed by an intermittent treatment with the same drugs for 6 to 9 months. The follow-up period was 7.5 years. Complete involution of the diseased lymph nodes was obtained in two thirds of the patients, partial involution in the remaining third. In one patient, a relapse occurred. The indications of this regimen are discussed.

• Authors: A Weinecke
• Journal: Zeitschrift fur Erkrankungen der Atmungsorgane (Z Erkr Atmungsorgane) Vol. 173 Issue 1 Pg. 63-7 ( 1989) ISSN: 0303-657X [Print] Germany
• Vernacular Title: Effektivität der INH-Rifampizin-Behandlung bei Lymphknotentuberkulose.
• PMID: 2800617 (Publication Type: English Abstract, Journal Article)

Chemical References

• Isoniazid
• Rifampin

Topics

• Adult
• Aged
• Aged, 80 and over
• Drug Therapy, Combination
• Humans
• Isoniazid (therapeutic use)
• Middle Aged
• Rifampin (therapeutic use)
• Tuberculosis, Lymph Node (drug therapy)