Abstract | BACKGROUND:
Chemotherapy-induced alopecia (CIA) is common in humans, but there are limited reports describing the clinical features of CIA in dogs. OBJECTIVES: To describe the epidemiological and clinical characteristics of doxorubicin-associated alopecia (DAA) in canine patients at a teaching hospital from 2012 to 2014. ANIMALS: Signalment, diagnosis, treatment protocols and clinical examination findings were recorded in 150 dogs treated with doxorubicin from 2012 to 2014. METHODS: Medical records were searched retrospectively for the keywords " alopecia" and " hypotrichosis." Dogs were excluded if the causal link of hair loss was unclear. RESULTS:
Doxorubicin-associated alopecia was reported in 28 of 150 dogs (19%). Two parameters were statistically associated with the development of DAA: coat-type and cumulative doxorubicin dose. Dogs with curly or wire-haired coat-type were significantly more likely to develop DAA than dogs with straight-haired coat-type [χ2 (1, N = 147) = 30, P < 0.0001]. After adjusting for sex, weight and doxorubicin dose, the odds of dogs with curly or wire-haired coat-type developing DAA were 22 times higher than those with straight-haired coat-type (P < 0.0001). Dogs that developed DAA received a significantly higher median cumulative doxorubicin dose (103.0 versus 84.5 mg/m2 ; P = 0.0039) than those that did not develop DAA. CONCLUSIONS AND CLINICAL IMPORTANCE: Dogs treated with doxorubicin may be at risk for developing DAA. This risk increases as the cumulative dose of doxorubicin increases, and with a curly or wire-haired coat-type.
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Authors | Elizabeth F Falk, Andrea T H Lam, Lisa G Barber, Lluis Ferrer |
Journal | Veterinary dermatology
(Vet Dermatol)
Vol. 28
Issue 2
Pg. 207-e48
(Apr 2017)
ISSN: 1365-3164 [Electronic] England |
PMID | 27976832
(Publication Type: Journal Article)
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Copyright | © 2016 ESVD and ACVD. |
Chemical References |
- Antibiotics, Antineoplastic
- Doxorubicin
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Topics |
- Alopecia
(chemically induced, veterinary)
- Animals
- Antibiotics, Antineoplastic
(adverse effects, therapeutic use)
- Dog Diseases
(chemically induced, drug therapy)
- Dogs
- Doxorubicin
(adverse effects, therapeutic use)
- Female
- Male
- Neoplasms
(drug therapy, veterinary)
- Retrospective Studies
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