Abstract | PURPOSE: METHODS: We separated 24 rabbits into 3 treatment groups in which topical drop treatment was placed onto the conjunctival cul-de-sac: (1) a single drop of controlled-release microspheres containing moxifloxacin, (2) a single drop of controlled-release microspheres without moxifloxacin, and (3) multiple topical treatment with moxifloxacin alone every 15 minutes for 1 hour. All rabbits were challenged, 1 hour after microspheres drop placement and immediately after the fifth topical dose of moxifloxacin, with anterior chamber injections of Staphylococcus aureus. Rabbits in the topical moxifloxacin group also were treated after challenge and four additional times over the next 24 hours. After 24 hours, the rabbits were clinically evaluated for endophthalmitis and the animals were euthanized to culture for intraocular S. aureus. The treatment groups were compared statistically for bacterial endophthalmitis. RESULTS: CONCLUSION: TRANSLATIONAL RELEVANCE: This study presents a simple method of prophylaxis to prevent postsurgical endophthalmitis.
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Authors | Alex Mammen, Eric G Romanowski, Morgan V Fedorchak, Deepinder K Dhaliwal, R M Shanks, Regis P Kowalski |
Journal | Translational vision science & technology
(Transl Vis Sci Technol)
Vol. 5
Issue 6
Pg. 12
(Dec 2016)
ISSN: 2164-2591 [Print] United States |
PMID | 27933222
(Publication Type: Journal Article)
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