A critical appraisal of the mild axonal peripheral neuropathy of late neurologic Lyme disease.

Abstract

In older studies, a chronic distal symmetric sensory neuropathy was reported as a relatively common manifestation of late Lyme disease in the United States. However, the original papers describing this entity had notable inconsistencies and certain inexplicable findings, such as reports that this condition developed in patients despite prior antibiotic treatment known to be highly effective for other manifestations of Lyme disease. More recent literature suggests that this entity is seen rarely, if at all. A chronic distal symmetric sensory neuropathy as a manifestation of late Lyme disease in North America should be regarded as controversial and in need of rigorous validation studies before acceptance as a documented clinical entity.

• Authors: Gary P Wormser, Franc Strle, Eugene D Shapiro, Raymond J Dattwyler, Paul G Auwaerter
• Journal: Diagnostic microbiology and infectious disease (Diagn Microbiol Infect Dis) Vol. 87 Issue 2 Pg. 163-167 (Feb 2017) ISSN: 1879-0070 [Electronic] United States
• PMID: 27914746 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2016 Elsevier Inc. All rights reserved.

Topics

• Americas
• Humans
• Lyme Neuroborreliosis (epidemiology, pathology)
• North America (epidemiology)
• Peripheral Nervous System Diseases (epidemiology, pathology)