Photodynamic therapy for the treatment of atherosclerotic plaque: Lost in translation?

Abstract

Acute coronary syndrome is a life-threatening condition of utmost clinical importance, which, despite recent progress in the field, is still associated with high morbidity and mortality. Acute coronary syndrome results from a rupture or erosion of vulnerable atherosclerotic plaque with secondary platelet activation and thrombus formation, which leads to partial or complete luminal obstruction of a coronary artery. During the last decade, scientific evidence demonstrated that when an acute coronary event occurs, several nonculprit plaques are in a "vulnerable" state. Among the promising approaches, several investigations provided evidence of photodynamic therapy (PDT)-induced stabilization and regression of atherosclerotic plaque. Significant development of PDT strategies improved its therapeutic outcome. This review addresses PDT's pertinence and major problems/challenges toward its translation to a clinical reality.

• Authors: Manish Jain, Matthieu Zellweger, Georges Wagnières, Hubert van den Bergh, Stéphane Cook, Marie-Noelle Giraud
• Journal: Cardiovascular therapeutics (Cardiovasc Ther) Vol. 35 Issue 2 (Apr 2017) ISSN: 1755-5922 [Electronic] England
• PMID: 27893195 (Publication Type: Journal Article, Review)
• Copyright: © 2016 John Wiley & Sons Ltd.

Chemical References

• Photosensitizing Agents

Topics

• Acute Coronary Syndrome (diagnostic imaging, drug therapy, pathology)
• Animals
• Coronary Artery Disease (diagnostic imaging, drug therapy, pathology)
• Coronary Vessels (diagnostic imaging, drug effects, pathology)
• Humans
• Photochemotherapy (adverse effects, methods)
• Photosensitizing Agents (adverse effects, therapeutic use)
• Plaque, Atherosclerotic
• Rupture, Spontaneous
• Theranostic Nanomedicine (methods)
• Translational Research, Biomedical
• Treatment Outcome