Short-term Intensive Immunosuppression: A Randomized, Three-arm Study of Intravenous Pulse Methylprednisolone and Cyclophosphamide in Macular Serpiginous Choroiditis.
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| Abstract | PURPOSE: To compare the efficacy of pulse cyclophosphamide with pulse dexamethasone in acute macular serpiginous choroiditis (SC). METHODS: A total of 30 patients with macular SC were prospectively randomized into three treatment groups: group D (pulse dexamethasone); group C (pulse cyclophosphamide); and combination (pulse group DCP) administered for 3 days. Macular SC was defined as any active lesion involving/threatening macula. RESULTS: A total of 30 patients were enrolled, with 10 patients in each group. Lesions completely healed at median duration of 2 weeks in each group, with significant improvement in visual acuity compared with pretreatment levels (p<0.05). Pulse cyclophosphamide was most effective in faster healing of lesions compared with other groups. There was no difference in gain in visual acuity between any of the groups (p = 0.32). CONCLUSIONS:
Cyclophosphamide may be an effective treatment modality for acute macular SC, though it may not have a long-term effect on disease relapse.
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| Authors | Pradeep Venkatesh, Akshay Tayade, Varun Gogia, Shikha Gupta, Bhavin M Shah, Rajpal Vohra |
| Journal | Ocular immunology and inflammation (Ocul Immunol Inflamm) Vol. 26 Issue 3 Pg. 469-476 ( 2018) ISSN: 1744-5078 [Electronic] England |
| PMID | 27849419 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial) |
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