HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Interaction Between Orexin-A and Sleep Quality in Females in Extreme Weight Conditions.

Abstract
The current study examined the relationship between plasma orexin-A and sleep in obesity. Concentrations of orexin-A and sleep were evaluated in 26 obese, 40 morbid obese and 32 healthy-weight participants. The sleep monitor Actiwatch AW7 and the Pittsburgh Sleep Quality Index were used to evaluate sleep. The Symptom Checklist-90-Revised was administered to assess symptoms of psychopathology. A higher weight status was associated with elevated orexin-A levels (p = .050), greater depression, anxiety and somatization symptoms (all: p < .001), and impoverished self-reported sleep quality (p < .001). A quadratic trend was found in objective sleep time, being longest in the obese group (p = .031). Structural equation modelling showed plasma orexin-A to be related to poor total sleep quality, which in turn was associated with elevated body mass index. Our data confirm an interaction between elevated plasma orexin-A concentrations and poor sleep that contributes to fluctuations in body mass index. Copyright © 2016 John Wiley & Sons, Ltd and Eating Disorders Association.
AuthorsSarah Sauchelli, Susana Jiménez-Murcia, Jose C Fernández-García, Lourdes Garrido-Sánchez, Francisco J Tinahones, Felipe F Casanueva, Rosa M Baños, Cristina Botella, Ana B Crujeiras, Rafael de la Torre, Jose M Fernández-Real, Gema Frühbeck, Roser Granero, Francisco J Ortega, Amaia Rodríguez, Stephan Zipfel, Katrin E Giel, Jose M Menchón, Fernando Fernández-Aranda
JournalEuropean eating disorders review : the journal of the Eating Disorders Association (Eur Eat Disord Rev) Vol. 24 Issue 6 Pg. 510-517 (11 2016) ISSN: 1099-0968 [Electronic] England
PMID27785902 (Publication Type: Journal Article)
CopyrightCopyright © 2016 John Wiley & Sons, Ltd and Eating Disorders Association.
Chemical References
  • Orexins
Topics
  • Adult
  • Anxiety (blood, psychology)
  • Body Mass Index
  • Body Weight
  • Case-Control Studies
  • Depression (blood, psychology)
  • Feeding and Eating Disorders
  • Female
  • Humans
  • Male
  • Obesity (blood, psychology)
  • Obesity, Morbid (blood, psychology)
  • Orexins (blood)
  • Overweight
  • Sleep (physiology)
  • Sleep Wake Disorders (blood, physiopathology)
  • Young Adult

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: