Abstract |
The current study examined the relationship between plasma orexin-A and sleep in obesity. Concentrations of orexin-A and sleep were evaluated in 26 obese, 40 morbid obese and 32 healthy-weight participants. The sleep monitor Actiwatch AW7 and the Pittsburgh Sleep Quality Index were used to evaluate sleep. The Symptom Checklist-90-Revised was administered to assess symptoms of psychopathology. A higher weight status was associated with elevated orexin-A levels (p = .050), greater depression, anxiety and somatization symptoms (all: p < .001), and impoverished self-reported sleep quality (p < .001). A quadratic trend was found in objective sleep time, being longest in the obese group (p = .031). Structural equation modelling showed plasma orexin-A to be related to poor total sleep quality, which in turn was associated with elevated body mass index. Our data confirm an interaction between elevated plasma orexin-A concentrations and poor sleep that contributes to fluctuations in body mass index. Copyright © 2016 John Wiley & Sons, Ltd and Eating Disorders Association.
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Authors | Sarah Sauchelli, Susana Jiménez-Murcia, Jose C Fernández-García, Lourdes Garrido-Sánchez, Francisco J Tinahones, Felipe F Casanueva, Rosa M Baños, Cristina Botella, Ana B Crujeiras, Rafael de la Torre, Jose M Fernández-Real, Gema Frühbeck, Roser Granero, Francisco J Ortega, Amaia Rodríguez, Stephan Zipfel, Katrin E Giel, Jose M Menchón, Fernando Fernández-Aranda |
Journal | European eating disorders review : the journal of the Eating Disorders Association
(Eur Eat Disord Rev)
Vol. 24
Issue 6
Pg. 510-517
(11 2016)
ISSN: 1099-0968 [Electronic] England |
PMID | 27785902
(Publication Type: Journal Article)
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Copyright | Copyright © 2016 John Wiley & Sons, Ltd and Eating Disorders Association. |
Chemical References |
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Topics |
- Adult
- Anxiety
(blood, psychology)
- Body Mass Index
- Body Weight
- Case-Control Studies
- Depression
(blood, psychology)
- Feeding and Eating Disorders
- Female
- Humans
- Male
- Obesity
(blood, psychology)
- Obesity, Morbid
(blood, psychology)
- Orexins
(blood)
- Overweight
- Sleep
(physiology)
- Sleep Wake Disorders
(blood, physiopathology)
- Young Adult
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