Abstract | BACKGROUND AND OBJECTIVE: METHODS: The human MC line LAD2 and primary MCs (human lung tissue MCs [hLMCs]) were used. MC mediator release was evaluated using the b- hexosaminidase and histamine release assay. The effects of rupatadine (H1 antagonist + PAF receptor antagonist), desloratadine, and levocetirizine (H1 antagonists) on LAD2 and hLMCs were compared. The PAF receptor antagonists WEB2086, BN52021, and CV6209 were also tested. PAF receptor protein expression was evaluated in both LAD2 and hLMCs. RESULTS: CONCLUSIONS:
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Authors | R Munoz-Cano, E Ainsua-Enrich, I Torres-Atencio, M Martin, J Sánchez-Lopez, J Bartra, C Picado, J Mullol, A Valero |
Journal | Journal of investigational allergology & clinical immunology
(J Investig Allergol Clin Immunol)
2017
Vol. 27
Issue 3
Pg. 161-168
ISSN: 1018-9068 [Print] Spain |
PMID | 27758758
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Azepines
- Fibrinolytic Agents
- Ginkgolides
- Histamine H1 Antagonists
- Histamine H1 Antagonists, Non-Sedating
- Lactones
- Platelet Activating Factor
- Platelet Aggregation Inhibitors
- Platelet Membrane Glycoproteins
- Pyridinium Compounds
- Receptors, G-Protein-Coupled
- Triazoles
- platelet activating factor receptor
- CV 6209
- WEB 2086
- rupatadine
- Cyproheptadine
- levocetirizine
- Loratadine
- ginkgolide B
- beta-N-Acetylhexosaminidases
- desloratadine
- Cetirizine
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Topics |
- Azepines
(pharmacology)
- Cell Degranulation
(drug effects)
- Cell Line
- Cetirizine
(pharmacology)
- Cyproheptadine
(analogs & derivatives, pharmacology)
- Fibrinolytic Agents
(pharmacology)
- Ginkgolides
(pharmacology)
- Histamine H1 Antagonists
(pharmacology)
- Histamine H1 Antagonists, Non-Sedating
(pharmacology)
- Humans
- Lactones
(pharmacology)
- Loratadine
(analogs & derivatives, pharmacology)
- Mast Cells
(drug effects)
- Platelet Activating Factor
(pharmacology)
- Platelet Aggregation Inhibitors
(pharmacology)
- Platelet Membrane Glycoproteins
(antagonists & inhibitors)
- Pyridinium Compounds
(pharmacology)
- Receptors, G-Protein-Coupled
(antagonists & inhibitors)
- Triazoles
(pharmacology)
- beta-N-Acetylhexosaminidases
(drug effects, metabolism)
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