Abstract | OBJECTIVES: Several researchers have reported the relationship between infertility in male and varicocele for so many years but the implication of varicocele in female patients is remains elusive. Here, we aim to examine the effects of unilateral varicose ovarian vein on antioxidant capacity and oocyte quality of rat ovary after the experimental creation of varicocele in female rats. MATERIALS AND METHODS: In this study, thirty adult female albino rats were divided into three equal groups: Group 1 as the control group has 10 rats, Group 2 as the sham group has 10 rats and they underwent a sham operation and finally Group 3 has the varicocele group has 10 rats. Antioxidant assays for superoxide dismutase, glutathione peroxidase and catalase were performed using specific assay kits and gene expression for Bax, Bmp-15, Hsp-27 and Gdf-9 was done via real time PCR. RESULTS: The adverse effects of the experimentally induced varicocele were reported and recorded on the left ovary compared to the right sided ovary (no varicocele induction) in the varicocele group. Real time PCR data shows that the expression of Gdf-9, Hsp-27 and Bmp-15 genes were all significantly reduced at p≤ 0.05. CONCLUSION:
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Authors | Babatunde Adebayo Kehinde, Farid Abolhassani, Hossein Yazdekhasti, Niloufar Abbasi, Leyla Heydari, Erfan Daneshi, Zahra Rajabi, Alaa Hamada, Ashok Agarwal, Mehdi Abbasi |
Journal | Iranian journal of basic medical sciences
(Iran J Basic Med Sci)
Vol. 19
Issue 8
Pg. 863-869
(Aug 2016)
ISSN: 2008-3866 [Print] Iran |
PMID | 27746868
(Publication Type: Journal Article)
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