Generalized Seizures after Experimental Traumatic Brain Injury Occur at the Transition from Slow-Wave to Rapid Eye Movement Sleep.

Abstract

Sleep disturbances commonly occur after traumatic brain injury (TBI) and may predispose patients to epileptic seizures. We hypothesized that unprovoked seizure occurrence post-TBI depends on the sleep-wake cycle, and that the electrographic characteristics of a given sleep stage provide biomarkers for post-traumatic epilepsy (PTE). We show, in a rat lateral fluid percussion model, that 92% of spontaneous generalized seizures occur during the transition from stage III to rapid eye movement sleep. Moreover, a reduction in spindle duration and dominant frequency during the transition stage present as specific and sensitive noninvasive biomarkers for experimentally induced PTE with generalized electrographic seizures.

• Authors: Pedro Andrade, Jari Nissinen, Asla Pitkänen
• Journal: Journal of neurotrauma (J Neurotrauma) Vol. 34 Issue 7 Pg. 1482-1487 (04 01 2017) ISSN: 1557-9042 [Electronic] United States
• PMID: 27707084 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Animals
• Brain Injuries, Traumatic (complications, physiopathology)
• Disease Models, Animal
• Epilepsy, Post-Traumatic (etiology, physiopathology)
• Male
• Rats
• Rats, Sprague-Dawley
• Sleep Stages (physiology)
• Sleep Wake Disorders (etiology, physiopathology)
• Sleep, REM (physiology)