Formulation of orodispersible films for paediatric therapy: investigation of feasibility and stability for tetrabenazine as drug model.

Abstract

OBJECTIVES:

Orodispersible films (ODF) were formulated to facilitate tetrabenazine (TBZ) administration to paediatric population for the treatment of hyperkinetic movement disorders.

METHODS:

ODF were obtained by solvent casting/evaporation method using four different polymers (HPMC, PVP, pullulan and HEC). Physicochemical, mechanical and biopharmaceutical characterizations as well as API state in ODF by thermal analysis were investigated to define and compare formulations. ODF stability was also monitored during 6 months to follow evolution of properties.

KEY FINDINGS:

Analyses at T0 showed few differences between formulations: results of physicochemical and mechanical characterizations were almost similar for each formulation and TBZ appeared at the amorphous state in all cases. ODF delivery system allowed a major improvement of TBZ dissolution profile in buccal conditions compared with pure drug. However, after 3 and 6 months of stability, a TBZ recrystallization occurred for formulations based on PVP and HEC associated with a decrease of drug release in saliva conditions.

CONCLUSIONS:

HPMC-ODF (F1) appeared as the best formulation. Indeed, physicochemical, mechanical and biopharmaceutical characteristic remained intact. In addition, TBZ remained in amorphous state during stability study.

• Authors: Zoé Senta-Loys, Sandrine Bourgeois, Cyril Pailler-Mattei, Géraldine Agusti, Stéphanie Briançon, Hatem Fessi
• Journal: The Journal of pharmacy and pharmacology (J Pharm Pharmacol) Vol. 69 Issue 5 Pg. 582-592 (May 2017) ISSN: 2042-7158 [Electronic] England
• PMID: 27671542 (Publication Type: Journal Article)
• Copyright: © 2016 Royal Pharmaceutical Society.

Chemical References

• Polymers
• Solvents
• Tetrabenazine

Topics

• Administration, Buccal
• Administration, Oral
• Chemistry, Pharmaceutical (methods)
• Drug Liberation (drug effects)
• Drug Stability
• Humans
• Hyperkinesis (drug therapy)
• Oral Mucosal Absorption
• Polymers (chemistry)
• Saliva (metabolism)
• Solubility
• Solvents (chemistry)
• Tetrabenazine (administration & dosage, chemistry)