The healing effect of Pistacia lentiscus fruit oil on laser burn.

Abstract

CONTEXT:

Since antiquity, Pistacia lentiscus L. (Anacardiaceae) fruit oil (PLFO) has been used as a remedy for primary health care such as burn treatment.

OBJECTIVE:

This study assesses the healing effect of PLFO on CO2 laser fractional burn in a rat model.

MATERIALS AND METHODS:

The study was carried out on 18 adult male Wistar rats. A second-degree laser burn (wound area = 2.2 cm2) was inflicted in the dorsal region by the application of CO2 fractional laser within the following parameters; Energy level: 25 MJ and Depth level: 4. After applying laser, the rats were divided into three groups: the first was treated with saline solution, the second with a reference cream 'CYTOL BASIC®' (0.13 μg/mm2) and the third with PLFO (0.52 μL/mm2). All treatments were topically administered for eight days. The healing effect was assessed using macroscopic, histological and biochemical parameters.

RESULTS:

After eight days, the higher percentage of wound healing contraction was observed among the PLFO-treated group (100%) followed by the 'CYTOL BASIC®' treated group (61.36%) and untreated group (32.27%). During the treatment, the PLFO-treated group showed less erythema, less crusting/scabbing, higher general wound appearance scores and a high content of collagen (220.67 ± 7.48 mg/g of tissue) than the other groups.

DISCUSSION AND CONCLUSION:

The current study has shown, for the first time, the healing effect of PLFO on CO2 laser fractional burn. Their wound healing effect could be attributed to their antimicrobial, anti-inflammatory and antioxidant effects.

• Authors: Sameh Ben Khedir, Sana Bardaa, Naourez Chabchoub, Dorsaf Moalla, Zouheir Sahnoun, Tarek Rebai
• Journal: Pharmaceutical biology (Pharm Biol) Vol. 55 Issue 1 Pg. 1407-1414 (Dec 2017) ISSN: 1744-5116 [Electronic] England
• PMID: 27659955 (Publication Type: Journal Article)

Chemical References

• Anti-Infective Agents
• Anti-Inflammatory Agents
• Antioxidants
• Dermatologic Agents
• Plant Extracts
• Plant Oils
• Collagen
• Hydroxyproline

Topics

• Animals
• Anti-Infective Agents (isolation & purification, pharmacology)
• Anti-Inflammatory Agents (isolation & purification, pharmacology)
• Antioxidants (isolation & purification, pharmacology)
• Burns (drug therapy, etiology, metabolism, pathology)
• Collagen (metabolism)
• Dermatologic Agents (isolation & purification, pharmacology)
• Disease Models, Animal
• Fruit (chemistry)
• Hydroxyproline (metabolism)
• Lasers, Gas
• Male
• Phytotherapy
• Pistacia (chemistry)
• Plant Extracts (isolation & purification, pharmacology)
• Plant Oils (isolation & purification, pharmacology)
• Plants, Medicinal
• Rats, Wistar
• Skin (drug effects, metabolism, pathology)
• Time Factors
• Wound Healing (drug effects)