The angiotensin-I converting enzyme gene I/D variation contributes to end-stage renal disease risk in Chinese patients with type 2 diabetes receiving hemodialysis.

Abstract

Whether the DD genotype of the angiotensin-I converting enzyme (ACE) I/D variation contributes to end-stage renal disease (ESRD) risk in type 2 diabetes mellitus (T2DM) remains controversial. Differences in study design, case and control definition, sample size and ethnicity may contribute to the discrepancies reported in association studies. We performed a case-control study to evaluate the association of the ACE I/D variation with ESRD risk in Chinese patients with T2DM receiving hemodialysis and analyzed the genotype-phenotype interaction. Unrelated Chinese patients (n = 432) were classified into the non-diabetic nephropathy (DN) control group (n = 222, duration of diabetes >10 years, no signs of renal involvement) and the DN-ESRD group (n = 210; ESRD due to T2DM, receiving hemodialysis). Polymerase chain reaction was used to genotype ACE I/D for all 432 subjects. The frequencies of the ID + DD genotypes were higher in the DN-ESRD group than non-DN control group (65.2 vs. 50.9 %; adjusted OR 1.98 (95 % CI, 1.31-3.00; P = 0.001). In the DN-ESRD group, the DD genotypic subgroup had significantly elevated HbA1c and diastolic blood pressure (DBP) compared to the II subgroup (both P < 0.05). The DD genotype of the ACE I/D variation may be associated with more elevated blood pressure and HbA1c, and therefore may predict the development, progression and severity of DN-ESRD in Chinese patients with T2DM undergoing hemodialysis.

• Authors: Ming Lu, Jianzhong Zhang, Ming Li, Xiaoxu Ge, Xu Dai, Jiao Zhao, Mingzhou Fu, Tao Wang, Xiyao Fang, Can Li, Rong Zhang, Weijing Zhao, Taishan Zheng, Feng Wang, Ming Yu, Tao Lei, Niansong Wang, Yuqian Bao, Limei Liu, Yanjun Liu, Weiping Jia
• Journal: Molecular and cellular biochemistry (Mol Cell Biochem) Vol. 422 Issue 1-2 Pg. 181-188 (Nov 2016) ISSN: 1573-4919 [Electronic] Netherlands
• PMID: 27633502 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• ACE protein, human
• Peptidyl-Dipeptidase A

Topics

• Aged
• Asian People
• China
• Diabetes Complications (enzymology, genetics, therapy)
• Diabetes Mellitus, Type 2 (epidemiology, genetics, therapy)
• Female
• Genetic Variation
• Genotype
• Humans
• Kidney Failure, Chronic (enzymology, genetics, therapy)
• Male
• Middle Aged
• Peptidyl-Dipeptidase A (genetics)
• Renal Dialysis