[Effect of molsidomine preparations on the contractile function of the myocardium and coronary circulation in patients with ischemic heart disease complicated by heart failure after isometric load].
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| Abstract |
Isometric stress tests were conducted in 95 coronary patients and 15 normal subjects. Load tests were repeated 1 hr after a single dose administration and at the end of a two-week treatment course. Left-ventricular contractility was found to be impaired at isometric stress in 66.7% of patients showing no clinical signs of heart failure, and coronary insufficiency was detected in 44.1%. A single molsidomin dose reduced diastolic and systolic left-ventricular volume by an average of 10.9 and 13.3%, respectively. At repeated isometric stress after molsidomin administration, only 15.7% of patients showed ischemic ST displacement on the electrocardiogram. Eleven (32.4%) of 34 patients with early phases of heart failure showed increased ejection fraction and a higher myocardial fibre circular shortening rate (by 4.9 and 11.7%, respectively) during hand grip under molsidomin effect. Long-term treatment with molsidomin preparations produced general improvement in 84.4% of patients, as reflected in the reduction of the signs of heart failure as well as the rate and intensity of anginal attacks.
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| Authors | E Z Alekperov |
| Journal | Kardiologiia (Kardiologiia) Vol. 29 Issue 4 Pg. 44-7 (Apr 1989) ISSN: 0022-9040 [Print] Russia (Federation) |
| Vernacular Title | Vliianie preparatov molsidimina na sokratitel'nuiu funktsiiu miokarda i koronarnoe krovoobrashchenie u bol'nykh ishemicheskoĭ bolezn'iu serdtsa, oslozhnennoĭ serdechnoĭ nedostatochnost'iu, v usloviiakh izometricheskoi nagruzki. |
| PMID | 2754913 (Publication Type: Comparative Study, English Abstract, Journal Article) |
| Chemical References |
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