Abstract |
The present study aimed to provide evidence on whether children at risk of gastrointestinal inflammation have increased measurements of faecal calprotectin (FC). FC was measured in 232 children; 55 children (n = 11 treatment naïve) with juvenile idiopathic arthritis (JIA), 63 with coeliac disease (CD); 17 with new diagnosis before and after treatment on gluten-free diet and 114 controls. None of the treatment-naive children with JIA had raised FC. Four JIA patients on treatment had a raised FC but in all cases a repeat test was normal. In newly diagnosed patients with CD, the median (interquartile range) FC was higher 36.4 (26-61) than that in controls 25.0 (23-41) mg/kg (P = 0.045) but this significantly decreased 25 (25-25) mg/kg (P = 0.012) after 6 months on gluten-free diet. Random measurements of FC are not raised in children with JIA or CD. A significant elevation of FC in these groups is not explained by their diagnosis and therefore needs further investigation.
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Authors | Olga Biskou, Janet Gardner-Medwin, Mary Mackinder, Martin Bertz, Clare Clark, Vaios Svolos, Richard K Russell, Christine A Edwards, Paraic McGrogan, Konstantinos Gerasimidis |
Journal | Journal of pediatric gastroenterology and nutrition
(J Pediatr Gastroenterol Nutr)
Vol. 63
Issue 5
Pg. e112-e115
(11 2016)
ISSN: 1536-4801 [Electronic] United States |
PMID | 27540707
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Leukocyte L1 Antigen Complex
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Topics |
- Arthritis, Juvenile
(complications)
- Celiac Disease
(complications, diagnosis)
- Child
- Child, Preschool
- Feces
(chemistry)
- Female
- Humans
- Leukocyte L1 Antigen Complex
(metabolism)
- Male
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