Optogenetic Approaches for Controlling Seizure Activity.

Abstract

Optogenetics, a technique that utilizes light-sensitive ion channels or pumps to activate or inhibit neurons, has allowed scientists unprecedented precision and control for manipulating neuronal activity. With the clinical need to develop more precise and effective therapies for patients with drug-resistant epilepsy, these tools have recently been explored as a novel treatment for halting seizure activity in various animal models. In this review, we provide a detailed and current summary of these optogenetic approaches and provide a perspective on their future clinical application as a potential neuromodulatory therapy.

• Authors: Jack K Tung, Ken Berglund, Robert E Gross
• Journal: Brain stimulation (Brain Stimul) 2016 Nov - Dec Vol. 9 Issue 6 Pg. 801-810 ISSN: 1876-4754 [Electronic] United States
• PMID: 27496002 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2016 Elsevier Inc. All rights reserved.

Topics

• Animals
• Humans
• Optogenetics (methods)
• Seizures (therapy)